ArticleProceedings of the National Academy of Sciences of the United States of America2018
Cellular function given parametric variation in the Hodgkin and Huxley model of excitability.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- In silico models in oncology, neurology, and epidemiology: systems-level and multiscale perspectives.NPJ systems biology and applications · 2026Review
- Neuronal excitability and parameter variability in the Hodgkin-Huxley model.PLoS computational biology · 2026Article
- Observing hidden neuronal states in experiments.PLoS computational biology · 2025Article
- A biophysical perspective on the resilience of neuronal excitability across timescales.Nature reviews. Neuroscience · 2023Review
- Sodium channel slow inactivation normalizes firing in axons with uneven conductance distributions.Current biology : CB · 2023Article
- A biophysical and statistical modeling paradigm for connecting neural physiology and function.Journal of computational neuroscience · 2023Article
- Neuronal morphology enhances robustness to perturbations of channel densities.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Reduced oriens-lacunosum/moleculare cell model identifies biophysical current balances forFrontiers in neural circuits · 2023Article
- Neuron populations use variable combinations of short-term feedback mechanisms to stabilize firing rate.PLoS biology · 2023Article
- Information geometry for multiparameter models: new perspectives on the origin of simplicity.Reports on progress in physics. Physical Society (Great Britain) · 2022Review
- Competency in Navigating Arbitrary Spaces as an Invariant for Analyzing Cognition in Diverse Embodiments.Entropy (Basel, Switzerland) · 2022Article
- The emergence of a collective sensory response threshold in ant colonies.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Multiple timescales in bacterial growth homeostasis.iScience · 2022Article
- The theoretical mechanism of Parkinson's oscillation frequency bands: a computational model study.Cognitive neurodynamics · 2021Article
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- Estimation of the Motor Threshold for Near-Rectangular Stimuli Using the Hodgkin-Huxley Model.Computational intelligence and neuroscience · 2021Article
- How is information transmitted in a nerve?Journal of biological physics · 2020Review
- Article
- Estimation of neuron parameters from imperfect observations.PLoS computational biology · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
How is reliable physiological function maintained in cells despite considerable variability in the values of key parameters of multiple interacting processes that govern that function? Here, we use the classic Hodgkin-Huxley formulation of the squid giant axon action potential to propose a possible approach to this problem. Although the full Hodgkin-Huxley model is very sensitive to fluctuations that independently occur in its many parameters, the outcome is in fact determined by simple combinations of these parameters along two physiological dimensions: structural and kinetic (denoted
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