ArticleArthritis research & therapy2018
The relationship between ferritin and urate levels and risk of gout.
Article in Arthritis research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Ferroptosis in gouty arthritis: a potential therapeutic strategy.Frontiers in immunology · 2026Pooled it
- A scoping review on cardiometabolic risk factors among Pacific Island populations and implications on future research in the region.American journal of epidemiology · 2026Article
- Hyperuricaemia in type 1 Gaucher disease: is uric acid a biomarker for disease severity?Internal medicine journal · 2025Article
- Iron metabolism in rheumatic diseases.Journal of translational autoimmunity · 2025Review
- Serum Uric Acid Levels and Bone Mineral Density in Peri- and Postmenopausal Korean Women: A Cross-sectional Study on 3,566 Cases.Archives of Iranian medicine · 2025Article
- A cross-sectional study of the association between blood metal mixtures exposure and hyperuricemia.Clinical rheumatology · 2024Article
- Integration of epidemiological and blood biomarker analysis links haem iron intake to increased type 2 diabetes risk.Nature metabolism · 2024Article
- Ferroptosis in Arthritis: Driver of the Disease or Therapeutic Option?International journal of molecular sciences · 2024Review
- Differential expression of ferroptosis-related proteins in urinary exosomes: potential indicators for monitoring acute gout attack.Frontiers in molecular biosciences · 2024Article
- Decoding ferroptosis: transforming orthopedic disease management.Frontiers in pharmacology · 2024Review
- Association between serum iron status and the risk of five bone and joint-related diseases: a Mendelian randomization analysis.Frontiers in endocrinology · 2024Article
- Mechanistic elucidation of ferroptosis and ferritinophagy: implications for advancing our understanding of arthritis.Frontiers in physiology · 2024Review
- Association of gout with brain reserve and vulnerability to neurodegenerative disease.Nature communications · 2023Article
- Ferroptosis in inflammatory arthritis: A promising future.Frontiers in immunology · 2022Review
- Modulation of Urate Transport by Drugs.Pharmaceutics · 2021Review
- Article
- Hereditary hemochromatosis disrupts uric acid homeostasis and causes hyperuricemia via altered expression/activity of xanthine oxidase and ABCG2.The Biochemical journal · 2020Article
- Association between anemia and hyperuricemia: results from the Korean National Health and Nutrition Examination Survey.Scientific reports · 2019Article
- The Paradoxical Role of Uric Acid in Osteoporosis.Nutrients · 2019Review
- Mouse models for human hyperuricaemia: a critical review.Nature reviews. Rheumatology · 2019Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFerritin positively associates with serum urate and an interventional study suggests that iron has a role in triggering gout flares. The objective of this study was to further explore the relationship between iron/ferritin and urate/gout.
methodsEuropean (100 cases, 60 controls) and Polynesian (100 cases, 60 controls) New Zealand (NZ) males and 189 US male cases and 60 male controls participated. The 10,727 participants without gout were from the Jackson Heart (JHS; African American = 1260) and NHANES III (European = 5112; African American = 4355) studies. Regression analyses were adjusted for age, sex, body mass index and C-reactive protein. To test for a causal relationship between ferritin and urate, bidirectional two-sample Mendelian randomization analysis was performed.
resultsSerum ferritin positively associated with gout in NZ Polynesian (OR (per 10 ng ml
conclusionsThese data replicate the association of ferritin with serum urate. Increased ferritin levels associated with gout and flare frequency. There was evidence of a causal effect of iron and ferritin on urate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.