Evidence map›Paper›PMID 30111326›Full record

ArticleRespiratory research2018

Age and African-American race impact the validity and reliability of the asthma control test in persistent asthmatics.

Allison J Burbank, Krista Todoric, Pamela Steele, Jonathan Rosen, Haibo Zhou, Marcia Frye, Ceila E Loughlin, Sally Ivins, Katherine Mills, Lauren Dembnicki Massey and 2 more

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Respiratory research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02662413 completednot on this map

To Determine the Measurement Properties of the ACT in an Adolescent Population With Persistent Asthma Followed at a Subspecialty Clinic.

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2016 to 2017Enrolled37ConditionsAsthmaArmsValidation of Asthma Control Questionnaire
NCT02671643 completednot on this map

To Determine the Measurement Properties of the ACT in an African American Adolescent Population With Persistent Asthma Followed at a Subspecialty Clinic

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2014 to 2017Enrolled54ConditionsAsthma
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Validation of an app-based portable spirometer in adolescents with asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Allison J BurbankDivision of Pediatric Allergy, Immunology and Rheumatology, University of North Carolina, Chapel Hill, NC, USA. Allison_burbank@med.unc.edu.ORCID http://orcid.org/0000-0002-5469-0225
Krista TodoricPenn State Hershey Allergy, Asthma & Immunology, Hershey, PA, USA.
Pamela SteeleDivision of Pediatric Allergy, Immunology and Rheumatology, University of North Carolina, Chapel Hill, NC, USA.
Jonathan RosenDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Haibo ZhouDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Marcia FryeNaval Medical Center Portsmouth, Portsmouth, VA, USA.
Ceila E LoughlinDivision of Pediatric Pulmonology, University of North Carolina, Chapel Hill, NC, USA.
Sally IvinsCenter for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, 104 Mason Farm Road, Chapel Hill, NC, 27599-7310, USA.
Katherine MillsCenter for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, 104 Mason Farm Road, Chapel Hill, NC, 27599-7310, USA.
Lauren Dembnicki MasseySandhills Pediatrics, Southern Pines, NC, USA.
Bryce B ReeveDepartment of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA.
Michelle L HernandezDivision of Pediatric Allergy, Immunology and Rheumatology, University of North Carolina, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · USDuke University · USNaval Medical Center Portsmouth · USPennsylvania State University · USSandhills Community College · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Statistical Methods for Cancer Clinical TrialsP01CA142538 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TSIATIS, ANASTASIOS A · 2010 to 2019
$21.3M
National Institutes of Health P01CA142538National Institutes of Health P30 ES010126National Institutes of Health R01ES021900NCI NIH HHS P01 CA142538NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

backgroundThe Asthma Control Test (ACT) is widely used to assess asthma control, yet the validity and reliability of the test have not been specifically evaluated in adolescents or African-Americans. We conducted a prospective psychometric study of the ACT in African-American (AA) and non-African-American (nAA) adolescents with persistent asthma, with emphasis on the clinical utility of the test for medical decision making.

methodsParticipants completed the ACT and performed spirometry. A physician conducted a guidelines-based assessment of asthma control, blinded to the ACT score. Study procedures were repeated 6-8 weeks later. The ACT-based asthma control assessment was compared to physician assessment.

resultsFor baseline and follow-up visits, internal consistency, as measured using Cronbach's alpha, was 0.80 and 0.81 in AA teens and 0.80 and 0.83 in nAA teens. Intraclass correlation coefficients were 0.59 and 0.76 in AA and nAA teens, respectively, with stable asthma control over time. Agreement between ACT and physician assessment was moderate in AA teens and fair in nAA teens. An ACT score of ≤19 showed reduced sensitivity for not well controlled asthma in both groups, while a score of ≤21 had the greatest area under the ROC curve. ACT scores were marginally responsive to change in control status.

conclusionsConcerns for the ACT's ability to detect uncontrolled asthma in adolescents emphasizes the need for a more comprehensive evaluation of asthma control in clinical settings. A higher threshold ACT score to define not well controlled asthma may be needed if the ACT is to be used for medical decision making.

trial registrationClinicalTrials.gov: NCT02671643 , NCT02662413 .

Indexed as

Black or African AmericanAdolescentAge FactorsAsthmaChildFemaleFollow-Up StudiesHumansMaleProspective StudiesReproducibility of ResultsSingle-Blind MethodSpirometrySurveys and QuestionnairesUnited StatesAdolescentAfrican-AmericanAsthmaControlQuestionnaireReliabilityThe asthma control test (ACT)Validity

Identifiers

PMID30111326
PMCPMC6094875
OpenAlexW2887642010

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.