Evidence map›Paper›PMID 30111184›Full record

ArticleThe American journal of psychiatry2018

Association of Maternal Insecticide Levels With Autism in Offspring From a National Birth Cohort.

Alan S Brown, Keely Cheslack-Postava, Panu Rantakokko, Hannu Kiviranta, Susanna Hinkka-Yli-Salomäki, Ian W McKeague, Heljä-Marja Surcel, Andre Sourander

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 5 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 5 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Pooled it
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  4. Early exposure to agricultural pesticides and the occurrence of autism spectrum disorder: a systematic review.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2022
    Pooled it
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  16. The Autism Spectrum Disorder and Its Possible Origins in Pregnancy.International journal of environmental research and public health · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Alan S BrownFrom the Department of Psychiatry, Columbia University Medical Center, and New York State Psychiatric Institute, New York; the Department of Epidemiology, Columbia University Mailman School of Public Health, New York; the Department of Health Security, National Institute for Health and Welfare, Kuopio, Finland; the Department of Child Psychiatry, University of Turku, Turku, Finland; the Department of Biostatistics, Columbia University Mailman School of Public Health, New York; the University of Oulu, Faculty of Medicine, Oulu, Finland; the Biobank Borealis of Northern Finland, Oulu University Hospital, Oulu, Finland; and the Department of Child Psychiatry, Turku University Hospital, Turku, Finland.
Keely Cheslack-PostavaFrom the Department of Psychiatry, Columbia University Medical Center, and New York State Psychiatric Institute, New York; the Department of Epidemiology, Columbia University Mailman School of Public Health, New York; the Department of Health Security, National Institute for Health and Welfare, Kuopio, Finland; the Department of Child Psychiatry, University of Turku, Turku, Finland; the Department of Biostatistics, Columbia University Mailman School of Public Health, New York; the University of Oulu, Faculty of Medicine, Oulu, Finland; the Biobank Borealis of Northern Finland, Oulu University Hospital, Oulu, Finland; and the Department of Child Psychiatry, Turku University Hospital, Turku, Finland.
Panu RantakokkoFrom the Department of Psychiatry, Columbia University Medical Center, and New York State Psychiatric Institute, New York; the Department of Epidemiology, Columbia University Mailman School of Public Health, New York; the Department of Health Security, National Institute for Health and Welfare, Kuopio, Finland; the Department of Child Psychiatry, University of Turku, Turku, Finland; the Department of Biostatistics, Columbia University Mailman School of Public Health, New York; the University of Oulu, Faculty of Medicine, Oulu, Finland; the Biobank Borealis of Northern Finland, Oulu University Hospital, Oulu, Finland; and the Department of Child Psychiatry, Turku University Hospital, Turku, Finland.
Hannu KivirantaFrom the Department of Psychiatry, Columbia University Medical Center, and New York State Psychiatric Institute, New York; the Department of Epidemiology, Columbia University Mailman School of Public Health, New York; the Department of Health Security, National Institute for Health and Welfare, Kuopio, Finland; the Department of Child Psychiatry, University of Turku, Turku, Finland; the Department of Biostatistics, Columbia University Mailman School of Public Health, New York; the University of Oulu, Faculty of Medicine, Oulu, Finland; the Biobank Borealis of Northern Finland, Oulu University Hospital, Oulu, Finland; and the Department of Child Psychiatry, Turku University Hospital, Turku, Finland.
Susanna Hinkka-Yli-SalomäkiFrom the Department of Psychiatry, Columbia University Medical Center, and New York State Psychiatric Institute, New York; the Department of Epidemiology, Columbia University Mailman School of Public Health, New York; the Department of Health Security, National Institute for Health and Welfare, Kuopio, Finland; the Department of Child Psychiatry, University of Turku, Turku, Finland; the Department of Biostatistics, Columbia University Mailman School of Public Health, New York; the University of Oulu, Faculty of Medicine, Oulu, Finland; the Biobank Borealis of Northern Finland, Oulu University Hospital, Oulu, Finland; and the Department of Child Psychiatry, Turku University Hospital, Turku, Finland.
Ian W McKeagueFrom the Department of Psychiatry, Columbia University Medical Center, and New York State Psychiatric Institute, New York; the Department of Epidemiology, Columbia University Mailman School of Public Health, New York; the Department of Health Security, National Institute for Health and Welfare, Kuopio, Finland; the Department of Child Psychiatry, University of Turku, Turku, Finland; the Department of Biostatistics, Columbia University Mailman School of Public Health, New York; the University of Oulu, Faculty of Medicine, Oulu, Finland; the Biobank Borealis of Northern Finland, Oulu University Hospital, Oulu, Finland; and the Department of Child Psychiatry, Turku University Hospital, Turku, Finland.
Heljä-Marja SurcelFrom the Department of Psychiatry, Columbia University Medical Center, and New York State Psychiatric Institute, New York; the Department of Epidemiology, Columbia University Mailman School of Public Health, New York; the Department of Health Security, National Institute for Health and Welfare, Kuopio, Finland; the Department of Child Psychiatry, University of Turku, Turku, Finland; the Department of Biostatistics, Columbia University Mailman School of Public Health, New York; the University of Oulu, Faculty of Medicine, Oulu, Finland; the Biobank Borealis of Northern Finland, Oulu University Hospital, Oulu, Finland; and the Department of Child Psychiatry, Turku University Hospital, Turku, Finland.
Andre SouranderFrom the Department of Psychiatry, Columbia University Medical Center, and New York State Psychiatric Institute, New York; the Department of Epidemiology, Columbia University Mailman School of Public Health, New York; the Department of Health Security, National Institute for Health and Welfare, Kuopio, Finland; the Department of Child Psychiatry, University of Turku, Turku, Finland; the Department of Biostatistics, Columbia University Mailman School of Public Health, New York; the University of Oulu, Faculty of Medicine, Oulu, Finland; the Biobank Borealis of Northern Finland, Oulu University Hospital, Oulu, Finland; and the Department of Child Psychiatry, Turku University Hospital, Turku, Finland.
Finnish Institute for Health and Welfare · FI

Funding

Prenatal factors and risk of autism in a Finnish national birth cohortR01ES019004 · NIEHS · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BROWN, ALAN STEWART · 2009 to 2017
$3.5M
NIEHS NIH HHS R01 ES019004
6 · The paper itself

Abstract

objectiveAutism is a complex neurodevelopmental disorder with a largely unknown etiology. To date, few studies have investigated prenatal exposure to toxins and risk of autism by using maternal biomarkers of exposure. Persistent organic pollutants are lipophilic halogenated organic compounds and include the insecticide dichlorodiphenyltrichloroethane (DDT), as well as its metabolite p,p'-dichlorodiphenyl dichloroethylene (p,p'-DDE), and polychlorinated biphenyls (PCBs). The objective of this study was to test whether elevated maternal levels of persistent organic pollutants are associated with autism among offspring.

methodThe investigation was derived from the Finnish Prenatal Study of Autism, a national birth cohort study based on a nested case-control design. Cases of autism among children born between 1987 and 2005 were ascertained by national registry linkages. In cases of childhood autism and matched control subjects (778 matched case-control pairs), maternal serum specimens from early pregnancy were assayed for levels of p,p'-DDE and total levels of PCBs.

resultsThe odds of autism among offspring were significantly increased with maternal p,p'-DDE levels that were in the highest 75th percentile, with adjustment for maternal age, parity, and history of psychiatric disorders (odds ratio=1.32, 95% CI=1.02, 1.71). The odds of autism with intellectual disability were increased by greater than twofold with maternal p,p'-DDE levels above this threshold (odds ratio=2.21, 95% CI=1.32, 3.69). There was no association between total levels of maternal PCBs and autism.

conclusionsThese findings provide the first biomarker-based evidence that maternal exposure to insecticides is associated with autism among offspring. Although further research is necessary to replicate this finding, this study has implications for the prevention of autism and may provide a better understanding of its pathogenesis.

Indexed as

Prenatal Exposure Delayed EffectsAir PollutantsAutistic DisorderChildCohort StudiesFemaleFinlandHumansInsecticidesIntellectual DisabilityMalePolychlorinated BiphenylsPregnancySex FactorsAir PollutantsInsecticidesPolychlorinated BiphenylsAutismBirth CohortEpidemiologyNeurodevelopmentPersistent Organic Pollutant

Identifiers

PMID30111184
PMCPMC6377859
OpenAlexW2887601144

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.