ArticleGenes2018
Pervasive Modulation of Obesity Risk by the Environment and Genomic Background.
Article in Genes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Dual exposure-by-polygenic score interactions highlight disparities across social groups in the proportion needed to benefit.medRxiv : the preprint server for health sciences · 2024Article
- Dysfunctional VLDL metabolism in MASLD.npj metabolic health and disease · 2024Review
- Applying an evolutionary mismatch framework to understand disease susceptibility.PLoS biology · 2023Article
- Canalization of the Polygenic Risk for Common Diseases and Traits in the UK Biobank Cohort.Molecular biology and evolution · 2022Article
- Findings from the Hispanic Community Health Study/Study of Latinos on the Importance of Sociocultural Environmental Interactors: Polygenic Risk Score-by-Immigration and Dietary Interactions.Frontiers in genetics · 2021Article
- Gene-obesogenic environment interactions on body mass indices for older black and white men and women from the Health and Retirement Study.International journal of obesity (2005) · 2020Article
- Genetic background and diet affect brown adipose gene coexpression networks associated with metabolic phenotypes.Physiological genomics · 2020Article
- The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly.Nature communications · 2020Article
- Environment and Gene Association With Obesity and Their Impact on Neurodegenerative and Neurodevelopmental Diseases.Frontiers in neuroscience · 2020Review
- Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank.Science advances · 2019Article
- Gene-Environment Interactions on Body Fat Distribution.International journal of molecular sciences · 2019Review
- Medicine in the Light of Evolution.Genes · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The prevalence of the so-called diseases of affluence, such as type 2 diabetes or hypertension, has increased dramatically in the last two generations. Although genome-wide association studies (GWAS) have discovered hundreds of genes involved in disease etiology, the sudden increase in disease incidence suggests a major role for environmental risk factors. Obesity constitutes a case example of a modern trait shaped by contemporary environment, although with considerable debates about the extent to which gene-by-environment (G×E) interactions accentuate obesity risk in individuals following obesogenic lifestyles. Although interaction effects have been robustly confirmed at the
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.