ReviewBritish journal of pharmacology2020
Neuronal histamine and the memory of emotionally salient events.
Review in British journal of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Histamine shapes the neurocomputational dynamics of human learning.Nature communications · 2026Article
- Targeting Microglia in Neuroinflammation: H3 Receptor Antagonists as a Novel Therapeutic Approach for Alzheimer's Disease, Parkinson's Disease, and Autism Spectrum Disorder.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Chemogenetic activation or inhibition of histaminergic neurons bidirectionally modulates recognition memory formation and retrieval in male and female mice.Scientific reports · 2024Article
- The Neurotransmission Basis of Post-Traumatic Stress Disorders by the Fear Conditioning Paradigm.International journal of molecular sciences · 2023Review
- Repurposing Histaminergic Drugs in Multiple Sclerosis.International journal of molecular sciences · 2022Article
- Brain systems in cocaine abstinence-induced anxiety-like behavior in rodents: A review.Addiction neuroscience · 2022Article
- Gut Barrier Dysfunction and Type 2 Immunity: Implications for Compulsive Behavior.Medical hypotheses · 2022Article
- Different Peas in the Same Pod: The Histaminergic Neuronal Heterogeneity.Current topics in behavioral neurosciences · 2022Review
- A Duet Between Histamine and Oleoylethanolamide in the Control of Homeostatic and Cognitive Processes.Current topics in behavioral neurosciences · 2022Review
- The Histamine and Multiple Sclerosis Alliance: Pleiotropic Actions and Functional Validation.Current topics in behavioral neurosciences · 2022Article
- The Histaminergic System in Neuropsychiatric Disorders.Biomolecules · 2021Review
- Chemogenetic modulation of histaminergic neurons in the tuberomamillary nucleus alters territorial aggression and wakefulness.Scientific reports · 2021Article
- Short- and Long-Term Social Recognition Memory Are Differentially Modulated by Neuronal Histamine.Biomolecules · 2021Article
- Carbonic anhydrase modulation of emotional memory. Implications for the treatment of cognitive disorders.Journal of enzyme inhibition and medicinal chemistry · 2020Article
- The role of carbonic anhydrases in extinction of contextual fear memory.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Neuronal histamine and the memory of emotionally salient events.British journal of pharmacology · 2020Review
- Challenges in the development and exploitation of new therapeutic options targeting the histaminergic system.British journal of pharmacology · 2020Article
- Histamine pharmacology: from Sir Henry Dale to the 21st century.British journal of pharmacology · 2020Review
- 4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as High-Affinity Non-imidazole Histamine HJournal of medicinal chemistry · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
In this review, we describe the experimental paradigms used in preclinical studies to unravel the histaminergic brain circuits that modulate the formation and retrieval of memories associated with aversive events. Emotionally arousing events, especially bad ones, are remembered more accurately, clearly and for longer periods of time than neutral ones. Maladaptive elaborations of these memories may eventually constitute the basis of psychiatric disorders such as generalized anxiety, obsessive-compulsive disorders and post-traumatic stress disorder. A better understanding of the role of the histaminergic system in learning and memory has not only a theoretical significance but also a translational value. Ligands of histamine receptors are among the most used drugs worldwide; hence, understanding the impact of these compounds on learning and memory may help improve their pharmacological profile and unravel unexplored therapeutic applications. LINKED ARTICLES: This article is part of a themed section on New Uses for 21st Century. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.3/issuetoc.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.