Observational studyRespiration; international review of thoracic diseases
Bronchial Thermoplasty-Induced Acute Airway Effects Assessed with Optical Coherence Tomography in Severe Asthma.
Observational study in Respiration; international review of thoracic diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Bronchial Thermoplasty Induced Changes in Blood Transcriptome Profile of Patients with Severe Asthma.International journal of molecular sciences · 2026Article
- Achieving remission in severe asthma.Chinese medical journal pulmonary and critical care medicine · 2025Review
- A Case Series of Patients Undergoing Bronchial Thermoplasty a Second Time for Severe Asthma.Journal of asthma and allergy · 2024Article
- Review
- In vivo polarisation sensitive optical coherence tomography for fibrosis assessment in interstitial lung disease: a prospective, exploratory, observational study.BMJ open respiratory research · 2023Observational
- Endobronchial Ultrasound is Useful in the Assessment of Bronchial Wall Changes Related to Bronchial Thermoplasty.Journal of asthma and allergy · 2023Article
- Knowledge gaps in the field of bronchial thermoplasty.Annals of translational medicine · 2022Article
- Recent advances in bronchial thermoplasty for severe asthma: a narrative review.Annals of translational medicine · 2022Review
- Evaluation of Tracheal Stenosis in Rabbits Using Multispectral Optoacoustic Tomography.Frontiers in bioengineering and biotechnology · 2022Article
- Airway Inflammation Before and After Bronchial Thermoplasty in Severe Asthma.Journal of asthma and allergy · 2022Article
- A case report of aspergillosis accompanied by saccular bronchodilation after bronchial thermoplasty in a 19-year-old woman.BMC pulmonary medicine · 2020Article
- Pharmacological ablation of the airway smooth muscle layer-Mathematical predictions of functional improvement in asthma.Physiological reports · 2020Article
- Can the Number of Radiofrequency Activations Predict Serious Adverse Events after Bronchial Thermoplasty? A Retrospective Case-Control Study.Pulmonary therapy · 2019Article
- Understanding the mechanism of bronchial thermoplasty using airway volume assessed by computed tomography.ERJ open research · 2019Article
- Article
- A case ofRespirology case reports · 2019Article
- European Respiratory Society International Congress, Paris, 2018: highlights from the Clinical Assembly.ERJ open research · 2019Review
- TGF-β1 induces airway smooth muscle cell proliferation and remodeling in asthmatic mice by up-regulating miR-181a and suppressing PTEN.International journal of clinical and experimental pathology · 2019Article
- Advances in Optical Coherence Tomography and Confocal Laser Endomicroscopy in Pulmonary Diseases.Respiration; international review of thoracic diseasesReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBronchial thermoplasty (BT) is an endoscopic treatment for severe asthma targeting airway smooth muscle (ASM) with radiofrequent energy. Although implemented worldwide, the effect of BT treatment on the airways is unclear. Optical coherence tomography (OCT) is a novel imaging technique, based on near-infrared light, that generates high-resolution cross-sectional airway wall images.
objectiveTo assess the safety and feasibility of OCT in severe asthma patients and determine acute airway effects of BT by OCT and compare these to the untreated right middle lobe (RML).
methodsSevere asthma patients were treated with BT (TASMA trial). During the third BT procedure, OCT imaging was performed immediately following BT in the airways of the upper lobes, the right lower lobe treated 6 weeks prior, and the untreated RML.
results57 airways were imaged in 15 patients. No adverse events occurred. Three distinct OCT patterns were discriminated: low-intensity scattering pattern of (1) bronchial and (2) peribronchial edema and (3) high-intensity scattering pattern of epithelial sloughing. (Peri)bronchial edema was seen in all BT-treated airways, and less pronounced in only 1/3 of the RML airways. These effects extended beyond the ASM layer and more distal than the directly BT-treated areas and were reduced, but not resolved, after 6 weeks. Epithelial sloughing occurred in 11/14 of the BT-treated airways and was absent in untreated RML airways.
conclusionsAcute BT effects can be safely assessed with OCT and 3 distinct patterns were identified. The acute effects extended beyond the targeted ASM layer and distal of directly BT-treated airway areas, suggesting that BT might also target smaller distal airways.
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