ArticleCell reports2018
Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal Function but Is Essential for Timely Axon Regeneration.
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Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.
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120 citing papers in PubMed, 172 citations in OpenAlex.
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60 more citing papers are in PubMed but not listed here.
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Authors and funding
21 authors at 5 institutions in 2 countries.
Alban LatremoliereKirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Long ChengKirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA; Department of Neurology, Boston Children's Hospital, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA.
Michelle DeLisleKirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA; Department of Neurology, Boston Children's Hospital, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Chen WuKirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA; Department of Neurology, Boston Children's Hospital, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA.
Sheena ChewKirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA; Department of Neurology, Boston Children's Hospital, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Elizabeth B HutchinsonQuantitative Medical Imaging Section, National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
Andrew SheridanDepartment of Neurology, Boston Children's Hospital, Boston, MA, USA.
Chloe AlexandreDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Frederic LatremoliereDepartment of Mathematics, University of Denver, Denver, CO, USA.
Shu-Hsien SheuDepartment of Pathology and Department of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Sara GolidyDepartment of Neurology, Boston Children's Hospital, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Takao OmuraKirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA; Department of Neurobiology, Harvard Medical School, Boston, MA, USA; Department of Orthopedic Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Eric A HuebnerKirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Yanjie FanKirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA; Department of Neurology, Boston Children's Hospital, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA.
Mary C WhitmanKirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA; Department of Ophthalmology, Boston Children's Hospital, Boston, MA, USA; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Elaine NguyenKirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA; Department of Ophthalmology, Boston Children's Hospital, Boston, MA, USA.
Crystal HermawanKirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA; Department of Neurology, Boston Children's Hospital, Boston, MA, USA.
Carlo PierpaoliQuantitative Medical Imaging Section, National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
Max A TischfieldKirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA; Department of Neurology, Boston Children's Hospital, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA.
Clifford J WoolfKirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Elizabeth C EngleKirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA; Department of Neurology, Boston Children's Hospital, Boston, MA, USA; Department of Ophthalmology, Boston Children's Hospital, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA. Electronic address: elizabeth.engle@childrens.harvard.edu.
Boston Children's Hospital · USHarvard University · USHenry M. Jackson Foundation · USNational Institute of Biomedical Imaging and Bioengineering · USUniversity of Denver · US
Funding
Unravelling Mechanisms and Novel Therapeutic Targets for Peripheral Neuropathy and Neuropathic Pain (Diversity Supplement)R35NS105076 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI WOOLF, CLIFFORD J · 2018 to 2025
$9.5MALTERED SENSIBILITY FOLLOWING PERIPHERAL NERVE DAMAGER01NS038253 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WOOLF, CLIFFORD J · 1999 to 2017
$8.2MMouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI CHEN, CHINFEI · 2016 to 2020
$5.2MSleep disturbance as a risk factor for developing chronic painR01DE022912 · NIDCR · BOSTON CHILDREN'S HOSPITAL · PI SCAMMELL, THOMAS E, WOOLF, CLIFFORD J · 2012 to 2016
$2.1MQuantitative Imaging in experimental models of traumatic brain injuryZIAEB000089 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI PIERPAOLI, CARLO · 2017 to 2020
$1.7MPediatric Pathology Translational ResearchT32HL110852 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI FLEMING, MARK D · 2012 to 2017
$1.4MOculomotor axon guidance in normal and abnormal developmentK08EY027850 · NEI · BOSTON CHILDREN'S HOSPITAL · PI WHITMAN, MARY CATHERINE · 2017 to 2019
$648kHoward Hughes Medical InstituteNEI NIH HHS K08 EY027850NHLBI NIH HHS T32 HL110852NICHD NIH HHS U54 HD090255NIDCR NIH HHS R01 DE022912NINDS NIH HHS R01 NS038253NINDS NIH HHS R35 NS105076
Abstract
We generated a knockout mouse for the neuronal-specific β-tubulin isoform Tubb3 to investigate its role in nervous system formation and maintenance. Tubb3
Indexed as
Action PotentialsAnimalsFemaleGanglia, SpinalGene Expression RegulationMaleMaze LearningMiceMice, KnockoutMicrotubulesNerve RegenerationNeuronal OutgrowthNeuronal PlasticityProtein IsoformsSignal TransductionTubulinProtein IsoformsTubb3 protein, mouseTubulinaxonal growthdevelopmentdiffusion tensor imagingmicrotubule dynamicsmousepost-translational modificationssensory recoveryspot cultureTUBB3tubulin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.