Evidence map›Paper›PMID 30110566›Full record

ArticleAmerican journal of physiology. Renal physiology2018

Absence of renal hypoxia in the subacute phase of severe renal ischemia-reperfusion injury.

Connie P C Ow, Jennifer P Ngo, Md Mahbub Ullah, Giannie Barsha, Ruth C Meex, Matthew J Watt, Lucinda M Hilliard, Maarten P Koeners, Roger G Evans

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. The Mechanisms of Ferroptosis Under Hypoxia.Cellular and molecular neurobiology · 2023
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. The role of oxidative stress and hypoxia in renal disease.Kidney research and clinical practice · 2019
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Connie P C OwCardiovascular Disease Program, Biomedicine Discovery Institute, Department of Physiology, Monash University , Melbourne, Victoria , Australia.
Jennifer P NgoCardiovascular Disease Program, Biomedicine Discovery Institute, Department of Physiology, Monash University , Melbourne, Victoria , Australia.ORCID 0000-0001-9980-9640
Md Mahbub UllahCardiovascular Disease Program, Biomedicine Discovery Institute, Department of Physiology, Monash University , Melbourne, Victoria , Australia.
Giannie BarshaCardiovascular Disease Program, Biomedicine Discovery Institute, Department of Physiology, Monash University , Melbourne, Victoria , Australia.
Ruth C MeexDepartment of Human Biology, NUTRIM School of Nutritional and Translational Research in Metabolism, Maastricht University Medical Centre , Maastricht , The Netherlands.
Matthew J WattMetabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Department of Physiology, Monash University, Melbourne, Victoria, Australia.
Lucinda M HilliardCardiovascular Disease Program, Biomedicine Discovery Institute, Department of Physiology, Monash University , Melbourne, Victoria , Australia.
Maarten P KoenersSchool of Physiology, Pharmacology and Neuroscience, Biomedical Sciences, University of Bristol , Bristol , United Kingdom.
Roger G EvansCardiovascular Disease Program, Biomedicine Discovery Institute, Department of Physiology, Monash University , Melbourne, Victoria , Australia.ORCID 0000-0002-9241-0757
Australian Regenerative Medicine Institute · AUMaastricht University Medical Centre · NLUniversity of Exeter · GB

Funding

British Heart Foundation FS/14/2/30630
6 · The paper itself

Abstract

Tissue hypoxia has been proposed as an important event in renal ischemia-reperfusion injury (IRI), particularly during the period of ischemia and in the immediate hours following reperfusion. However, little is known about renal oxygenation during the subacute phase of IRI. We employed four different methods to assess the temporal and spatial changes in tissue oxygenation during the subacute phase (24 h and 5 days after reperfusion) of a severe form of renal IRI in rats. We hypothesized that the kidney is hypoxic 24 h and 5 days after an hour of bilateral renal ischemia, driven by a disturbed balance between renal oxygen delivery (Do

Indexed as

Oxygen ConsumptionAcute Kidney InjuryAnimalsBasic Helix-Loop-Helix ProteinsCell HypoxiaDisease Models, AnimalEndothelial PAS Domain-Containing Protein 1HemodynamicsHypoxia-Inducible Factor 1, alpha SubunitKidneyMaleOxygenRats, Sprague-DawleyRenal CirculationReperfusion InjurySeverity of Illness IndexBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1Hif1a protein, ratHypoxia-Inducible Factor 1, alpha SubunitOxygenacute kidney injuryhypoxiaischemia-reperfusionkidneyoxygen

Identifiers

PMID30110566
PMCPMC6293301
OpenAlexW2886059695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.