Evidence map›Paper›PMID 30110564›Full record

ArticleAmerican journal of physiology. Cell physiology2018

Hydrogen sulfide alleviates hyperhomocysteinemia-mediated skeletal muscle atrophy via mitigation of oxidative and endoplasmic reticulum stress injury.

Avisek Majumder, Mahavir Singh, Jyotirmaya Behera, Nicholas T Theilen, Akash K George, Neetu Tyagi, Naira Metreveli, Suresh C Tyagi

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 58 citations in OpenAlex.

  1. Significance of GSH and HRedox report : communications in free radical research · 2026
    Review
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  6. CSE/HInternational journal of molecular sciences · 2025
    Review
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  15. Characterization of Glutathione Dithiophosphates as Long-Acting HInternational journal of molecular sciences · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Beneficial Effect of HInternational journal of molecular sciences · 2022
    Article
  20. HFrontiers in physiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Avisek MajumderDepartment of Physiology, University of Louisville School of Medicine , Louisville, Kentucky.
Mahavir SinghDepartment of Physiology, University of Louisville School of Medicine , Louisville, Kentucky.
Jyotirmaya BeheraDepartment of Physiology, University of Louisville School of Medicine , Louisville, Kentucky.
Nicholas T TheilenDepartment of Physiology, University of Louisville School of Medicine , Louisville, Kentucky.
Akash K GeorgeDepartment of Physiology, University of Louisville School of Medicine , Louisville, Kentucky.
Neetu TyagiDepartment of Physiology, University of Louisville School of Medicine , Louisville, Kentucky.
Naira MetreveliDepartment of Physiology, University of Louisville School of Medicine , Louisville, Kentucky.
Suresh C TyagiDepartment of Physiology, University of Louisville School of Medicine , Louisville, Kentucky.
University of Louisville · US

Funding

FOCUS Data Coordinating CenterU01HL074815 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI TERRIN, MICHAEL L · 2003 to 2010
$2.9M
Mechanisms of Homocysteine-Induced Fibrinogen-Amyloid Plaque FormationR01NS084823 · NINDS · UNIVERSITY OF LOUISVILLE · PI LOMINADZE, DAVID, TYAGI, SURESH C. · 2013 to 2017
$2.7M
Mechanisms of Mitochondrial Dysfunction in Brain VasculatureR01HL107640 · NHLBI · UNIVERSITY OF LOUISVILLE · PI TYAGI, NEETU · 2012 to 2016
$1.8M
NHLBI NIH HHS R01 HL107640NHLBI NIH HHS U01 HL074815NINDS NIH HHS R01 NS084823
6 · The paper itself

Abstract

Although hyperhomocysteinemia (HHcy) occurs because of the deficiency in cystathionine-β-synthase (CBS) causing skeletal muscle dysfunction, it is still unclear whether this effect is mediated through oxidative stress, endoplasmic reticulum (ER) stress, or both. Nevertheless, there is no treatment option available to improve HHcy-mediated muscle injury. Hydrogen sulfide (H

Indexed as

Activating Transcription Factor 6AnimalsAntioxidantsCystathionine beta-SynthaseEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressEndoribonucleasesForkhead Box Protein O1Gene Expression RegulationHeat-Shock ProteinsHumansHyperhomocysteinemiaInterleukin-6MAP Kinase Kinase 4MiceMuscle ProteinsActivating Transcription Factor 6AntioxidantsAtf6 protein, mouseCystathionine beta-SynthaseEndoplasmic Reticulum Chaperone BiPEndoribonucleasesErn1 protein, mouseFbxo32 protein, mouseForkhead Box Protein O1Foxo1 protein, mouseHeat-Shock ProteinsHSPA5 protein, humanHspa5 protein, mouseInterleukin-6MAP Kinase Kinase 4Muscle ProteinsProtein Serine-Threonine KinasesSKP Cullin F-Box Protein Ligasessodium hydrogen sulfiteSulfitesTrim63 protein, mouseTripartite Motif ProteinsTumor Necrosis Factor-alphaUbiquitin-Protein Ligasescellular stresscystathionine-β-synthaseinflammationmuscle atrophyreactive oxygen species

Identifiers

PMID30110564
PMCPMC6293052
OpenAlexW2886817845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.