ArticleRoyal Society open science2018
Synthesis of 1,8-naphthalimide-based probes with fluorescent switch triggered by flufenamic acid.
Article in Royal Society open science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 38 citations in OpenAlex.
- Design and Enzyme-Targeted Assessment of 1,2,4-Triazole-1,8-Naphthalimide Hybrids in Drug Discovery.BioMed research international · 2025Article
- Unusual enantioselective cytoplasm-to-nucleus translocation and photosensitization of the chiral Ru(II) cationic complex via simple ion-pairing with lipophilic weak acid counter-anions.Nucleic acids research · 2023Article
- Six New Unsymmetrical Imino-1,8-naphthalimide Derivatives Substituted at 3-C Position-Photophysical Investigations.Materials (Basel, Switzerland) · 2022Article
- Synthesis and Solvent Dependent Fluorescence of Some Piperidine-Substituted Naphthalimide Derivatives and Consequences for Water Sensing.International journal of molecular sciences · 2022Article
- Article
- New Acceptor-Donor-Acceptor Systems Based on Bis-(Imino-1,8-Naphthalimide).Materials (Basel, Switzerland) · 2021Article
- Effect of an alkyl spacer on the morphology and internalization of MUC1 aptamer-naphthalimide amphiphiles for targeting and imaging triple negative breast cancer cells.Bioengineering & translational medicine · 2021Article
- Fluorescent Imprinted Nanoparticles for the Effective Monitoring of Irinotecan in Human Plasma.Nanomaterials (Basel, Switzerland) · 2020Article
- Selective Recognition of Herbicides in Water Using a Fluorescent Molecularly Imprinted Polymer Sensor.Journal of fluorescence · 2020Article
- Naphthalimide-based optical turn-on sensor for monosaccharide recognition using boronic acid receptor.RSC advances · 2019Article
- Induction ofFrontiers in immunology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work, we report the synthesis of novel fluorescent molecules, based on 1,8-naphthalimide thio- and amino-derivatives, designed to display an OFF-ON and ON-OFF photoelectron transfer fluorescence switch upon interaction with a proton-donor drug. We have functionalized the new probes to allow easy formation of a covalent link to polymer matrices, for future applications as drug delivery sensors. We have investigated the fluorescent switch of the new probes using flufenamic acid (FA, pKa 3.65), a water insoluble, non-steroidal anti-inflammatory drug, as a model drug and proton source. The rapid interaction of the new probes with FA resulted in fluorescence enhancement or decrease and a large Stokes shift, all of which allowed the detection of the drug in the nanomolar range. The new 1,8-naphthalimide fluorescent dyes reported in this work are interesting tools for the detection and quantification of acidic drugs and biomolecules.
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