Evidence map›Paper›PMID 30110191›Full record

ArticleGut microbes2019

Silence is golden: gene silencing of V. cholerae during intestinal colonization delivers new aspects to the acid tolerance response.

Fatih Cakar, Franz G Zingl, Stefan Schild

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. TetR RegulatedBio-protocol · 2020
    Article
  5. Article
  6. Virulence Regulation and Innate Host Response in the Pathogenicity ofFrontiers in cellular and infection microbiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Fatih Cakara Institute of Molecular Biosciences , University of Graz , Graz , Austria.
Franz G Zingla Institute of Molecular Biosciences , University of Graz , Graz , Austria.
Stefan Schilda Institute of Molecular Biosciences , University of Graz , Graz , Austria.ORCID 0000-0001-7842-0177
University of Graz · AT

Funding

Austrian Science Fund FWF P 25691Austrian Science Fund FWF P 27654
6 · The paper itself

Abstract

Bacterial pathogens of the gastrointestinal tract alter their expression profile upon ingestion by the host and activate a variety of factors enhancing colonization and virulence. However, gene silencing during infection might be as important as gene activation to achieve full colonization fitness. Thus, we developed and successfully applied a reporter technology to identify 101 in vivo repressed (ivr) genes of the bacterial pathogen Vibrio cholerae. In depth analysis of the in vivo repressed H

Indexed as

Gene SilencingAcidsAdaptation, PhysiologicalAnimalsAntiportersBacterial ProteinsCholeraDisease Models, AnimalGastrointestinal TractGene Expression Regulation, BacterialHost-Pathogen InteractionsMutationVibrio choleraeVirulenceAcidsAntiportersBacterial Proteinsbacterial pathogenesischoleracolonization fitnessgene repressionHost-pathogen interactionsin vivo gene regulationmurine modelspatiotemporal gene regulationTRIVETvirlulence

Identifiers

PMID30110191
PMCPMC6546326
OpenAlexW2886572267

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.