ArticleRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
Intermittent hypoxia, brain glyoxalase-1 and glutathione reductase-1, and anxiety-like behavior in mice.
Article in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Nocturnal hypoxia moderates the relationship between rapid eye movement sleep and anxiety.BMC psychiatry · 2025Article
- Central glutathione mitigates obesity-induced social phobia: evidence from human and animal studies.Archives of endocrinology and metabolism · 2025Article
- Functional cobalt-doped hydrogel scaffold enhances concurrent vascularization and neurogenesis.Journal of nanobiotechnology · 2025Article
- Treadmill Training-Induced Remyelination Rescues Cognitive Impairment After Acute Hypoxia.Neurochemical research · 2025Article
- Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis.Neural regeneration research · 2024Review
- Age-related changes in the architecture and biochemical markers levels in motor-related cortical areas of SHR rats-an ADHD animal model.Frontiers in molecular neuroscience · 2024Article
- Long-term intermittent hypoxia induces anxiety-like behavior and affects expression of orexin and its receptors differently in the mouse brain.Sleep and biological rhythms · 2023Article
- Explicit memory, anxiety and depressive like behavior in mice exposed to chronic intermittent hypoxia, sleep fragmentation, or both during the daylight period.Neurobiology of sleep and circadian rhythms · 2022Article
- Insight into the Effects of High-Altitude Hypoxic Exposure on Learning and Memory.Oxidative medicine and cellular longevity · 2022Review
- The role of hypoxia in stem cell regulation of the central nervous system: From embryonic development to adult proliferation.CNS neuroscience & therapeutics · 2021Review
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Authors and funding
7 authors.
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Abstract
objectiveSleep apnea has been associated with anxiety, but the mechanisms of the sleep apnea-anxiety relationship are unresolved. Sleep apnea causes oxidative stress, which might enhance anxiety-like behavior in rodents. To clarify the apnea-anxiety connection, we tested the effect of intermittent hypoxia, a model of sleep apnea, on the anxiety behavior of mice.
methodsThe rodents were exposed daily to 480 one-minute cycles of intermittent hypoxia to a nadir of 7±1% inspiratory oxygen fraction or to a sham procedure with room air. After 7 days, the mice from both groups were placed in an elevated plus maze and were video recorded for 10 min to allow analysis of latency, frequency, and duration in open and closed arms. Glyoxalase-1 (Glo1) and glutathione reductase-1 (GR1) were measured in the cerebral cortex, hippocampus, and striatum by Western blotting.
resultsCompared to controls, the intermittent hypoxia group displayed less anxiety-like behavior, perceived by a statistically significant increase in the number of entries and total time spent in open arms. A higher expression of GR1 in the cortex was also observed.
conclusionThe lack of a clear anxiety response as an outcome of intermittent hypoxia exposure suggests the existence of additional layers in the anxiety mechanism in sleep apnea, possibly represented by sleepiness and irreversible neuronal damage.
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