ArticleClinics (Sao Paulo, Brazil)2018
Relationships between female infertility and female genital infections and pelvic inflammatory disease: a population-based nested controlled study.
Article in Clinics (Sao Paulo, Brazil), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 57 citations in OpenAlex.
- Differences in Vaginal Microbiota Composition Between Infertile and Fertile Patients: A Prospective Study.Diagnostics (Basel, Switzerland) · 2025Article
- Association between ultra-processed foods and female infertility: a large cross-sectional study.BMC public health · 2025Article
- Article
- Assessing the quality of gynaecological care in China: protocol for a nationwide survey using mixed-methods.BMJ open · 2025Article
- Study on the Status of Gamete Freezing and Reproductive Health of Korean Adults Aged 19-49 Years.Healthcare (Basel, Switzerland) · 2025Article
- Association between bacterial vaginosis, Chlamydia trachomatis infection and tubal factor infertility in Bukavu, Democratic Republic of Congo.BMC infectious diseases · 2024Article
- Abdominal Pain and Fever 48 Hours After Hysterosalpingography.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2023Article
- The role of systemic immune inflammation index in predicting treatment success in tuboovarian abscesses.Archives of gynecology and obstetrics · 2023Article
- Diagnosed Gonorrhea Among Privately Insured Women: Analysis of United States Claims Data.Journal of women's health (2002) · 2023Article
- Article
- Autologous Human Mesenchymal Stem Cell-Based Therapy in Infertility: New Strategies and Future Perspectives.Biology · 2023Review
- Patterns of pediatric and adolescent female genital inflammation in China: an eight-year retrospective study of 49,175 patients in China.Frontiers in public health · 2023Observational
- Satisfaction with the life of Polish women experiencing domestic violence.Frontiers in public health · 2023Article
- Chlamydia infection, PID, and infertility: further evidence from a case-control study in China.BMC women's health · 2022Article
- A perforated sigmoid colon cancer initially diagnosed as a tubo-ovarian abscess: A teaching case.Clinical case reports · 2022Article
- Increased serum LOXL2 concentration in pelvic inflammatory disease with pelvic adhesion.BMC women's health · 2022Article
- Article
- 2,3,5,4'-Tetrahydroxystilbene-2-Frontiers in cell and developmental biology · 2022Article
- Fibronectin Molecular Status in Plasma of Women with Endometriosis and Fertility Disorders.International journal of molecular sciences · 2021Article
- The Role of AIRE Deficiency in Infertility and Its Potential Pathogenesis.Frontiers in immunology · 2021Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesOur purpose was to examine the associations of female genital infections and certain comorbidities with infertility.
methodsThe Taiwan National Health Research Database was searched for women with a new diagnosis of infertility between 2000 and 2013. Women without a diagnosis of infertility served as a control group and were matched with the infertility cases by age (±3 years) and index year. They were divided into two groups: ≤40 years old and >40 years old. Univariate and multivariate conditional logistic regression models were employed to identify the risk factors associated with infertility.
resultsA total of 18,276 women with a new diagnosis of infertility and 73,104 matched controls (mean cohort age, 31±6.2 years) were included. According to the adjusted multivariate analysis, pelvic inflammatory disease involving the ovary, fallopian tube, pelvic cellular tissue, peritoneum (odds ratio (OR)=4.823), and uterus (OR=3.050) and cervical, vaginal, and vulvar inflammation (OR=7.788) were associated with an increased risk of infertility in women aged ≤40 years. In women aged >40 years, pelvic inflammatory disease of the ovary, fallopian tube, pelvic cellular tissue, and peritoneum (OR=6.028) and cervical, vaginal, and vulvar inflammation (OR=6.648) were associated with infertility. Obesity, lipid metabolism disorders, dysthyroidism, abortion (spontaneous or induced), bacterial vaginosis, endometritis, and tubo-ovarian abscess were associated with an increased risk of infertility according to the univariate analysis but not the multivariate analysis.
conclusionsFemale genital tract infections, but not the comorbidities studied here, are associated with an increased risk of infertility.
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