Evidence map›Paper›PMID 30109984›Full record

ArticleeLife2018

Optogenetic dissection of mitotic spindle positioning in vivo.

Lars-Eric Fielmich, Ruben Schmidt, Daniel J Dickinson, Bob Goldstein, Anna Akhmanova, Sander van den Heuvel

Abstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. LGL-1 and the RhoGAP protein PAC-1 redundantly polarize thebioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Marine Model Organisms for Mechanobiology Studies.Results and problems in cell differentiation · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Exclusion of the endoplasmic reticulum from themicroPublication biology · 2025
    Article
  14. Article
  15. A cytokinetic ring-driven cell rotation achieves Hertwig's rule in early development.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Article
  17. Review
  18. Mechanisms underlying spindle assembly and robustness.Nature reviews. Molecular cell biology · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Lars-Eric Fielmich *Developmental Biology, Department of Biology, Faculty of Sciences, Utrecht University, Utrecht, Netherlands.ORCID 0000-0003-0247-1298
Ruben Schmidt *Developmental Biology, Department of Biology, Faculty of Sciences, Utrecht University, Utrecht, Netherlands.ORCID 0000-0001-9187-5424
Daniel J DickinsonLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID 0000-0003-2651-2584
Bob GoldsteinLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID 0000-0001-6961-675X
Anna AkhmanovaCell Biology, Department of Biology, Faculty of Sciences, Utrecht University, Utrecht, Netherlands.ORCID 0000-0002-9048-8614
Sander van den HeuvelDevelopmental Biology, Department of Biology, Faculty of Sciences, Utrecht University, Utrecht, Netherlands.ORCID 0000-0001-9015-7463

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Mechanisms of C. elegans GastrulationR01GM083071 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GOLDSTEIN, ROBERT P · 2008 to 2019
$3.7M
Biochemical Basis of Cell Polarization by the PAR Protein SystemR00GM115964 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI DICKINSON, DANIEL J · 2018 to 2020
$747k
European Research Council Synergy grant 609822Nederlandse Organisatie voor Wetenschappelijk Onderzoek NWO TOP/ECHO grant 711.015.001NIGMS NIH HHS R00 GM115964NIGMS NIH HHS R01 GM083071NIH HHS NIH K99 GM115964NIH HHS NIH R01 GM083071NIH HHS P40 OD010440
6 · The paper itself

Abstract

The position of the mitotic spindle determines the plane of cell cleavage, and thereby daughter cell location, size, and content. Spindle positioning is driven by dynein-mediated pulling forces exerted on astral microtubules, which requires an evolutionarily conserved complex of Gα∙GDP, GPR-1/2

Indexed as

OptogeneticsAllelesAnimalsBiomechanical PhenomenaCaenorhabditis elegansCaenorhabditis elegans ProteinsCell MembraneCodonDyneinsEmbryo, NonmammalianGene Expression RegulationGenes, EssentialGerm CellsGTP-Binding Protein alpha SubunitsLightSpindle ApparatusCaenorhabditis elegans ProteinsCodonDyneinsGTP-Binding Protein alpha SubunitsC. eleganscell biologycell divisiondevelopmental biologydyneingermline silencingLIN-5 (NuMA)mitotic spindle positioningoptogenetics

Identifiers

PMID30109984
PMCPMC6214656

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.