Evidence map›Paper›PMID 30109823›Full record

ReviewPhysiology (Bethesda, Md.)2018

Defining the Rhythmogenic Elements of Mammalian Breathing.

Jan-Marino Ramirez, Nathan Baertsch

Open access · bronzeAbstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 82 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Dynamics of neural activity in early nervous system evolution.Current opinion in behavioral sciences · 2024
    Article
  12. Article
  13. Article
  14. Current definitions of the breathing cycle in alveolar breath-by-breath gas exchange analysis.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Review
  15. Role of NaCell reports · 2023
    Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Inspiratory rhythm generation is stabilized byJournal of neurophysiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jan-Marino RamirezCenter for Integrative Brain Research, Seattle Children's Research Institute, University of Washington School of Medicine , Seattle, Washington.
Nathan BaertschCenter for Integrative Brain Research, Seattle Children's Research Institute, University of Washington School of Medicine , Seattle, Washington.
University of Washington · US

Funding

Integrative Consequences of HypoxiaP01HL090554 · NHLBI · UNIVERSITY OF CHICAGO · PI PRABHAKAR, NANDURI R · 2008 to 2017
$21.4M
Unraveling respiratory rhythm generation in the medullary networkR01HL126523 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI Jan M. Ramirez · 2015 to 2026
$8.3M
The role of Dbx1-derived medullary neurons for rhythm generation in the intact respiratory networkF32HL134207 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI BAERTSCH, NATHAN ANDREW · 2016 to 2018
$139k
NHLBI NIH HHS F32 HL134207NHLBI NIH HHS P01 HL090554NHLBI NIH HHS R01 HL126523
6 · The paper itself

Abstract

Breathing's remarkable ability to adapt to changes in metabolic, environmental, and behavioral demands stems from a complex integration of its rhythm-generating network within the wider nervous system. Yet, this integration complicates identification of its specific rhythmogenic elements. Based on principles learned from smaller rhythmic networks of invertebrates, we define criteria that identify rhythmogenic elements of the mammalian breathing network and discuss how they interact to produce robust, dynamic breathing.

Indexed as

AnimalsHumansMammalsNerve NetNeuronsPeriodicityRespiration

Identifiers

PMID30109823
PMCPMC6230551
OpenAlexW2885991550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.