ReviewCerebellum (London, England)2019
Common Genetic Variants Link the Abnormalities in the Gut-Brain Axis in Prematurity and Autism.
Review in Cerebellum (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- The Effect of Gluten-Free Diet on Gastrointestinal Symptoms and Disease Severity of Autistic Children: A Randomized Controlled Trial.Iranian journal of child neurology · 2026Article
- Prematurity and genetic liability for autism spectrum disorder.Genome medicine · 2025Article
- Prematurity and Genetic Liability for Autism Spectrum Disorder.medRxiv : the preprint server for health sciences · 2025Article
- Unexplained gut symptoms in extremely preterm infants are associated with gastrointestinal dysfunction at 5.5 years.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Identifying understudied correlations between autism & phenotypic attributes in a large family dataset.BMC psychology · 2025Article
- Exposure to prescribed medication in early life and impacts on gut microbiota and disease development.EClinicalMedicine · 2024Review
- Vasopressin as Possible Treatment Option in Autism Spectrum Disorder.Biomedicines · 2023Review
- Gut Microbiome-Brain Axis as an Explanation for the Risk of Poor Neurodevelopment Outcome in Preterm Infants with Necrotizing Enterocolitis.Microorganisms · 2023Review
- Associations between Symptom Severity of Autism Spectrum Disorder and Screen Time among Toddlers Aged 16 to 36 Months.Behavioral sciences (Basel, Switzerland) · 2023Article
- Communication of gut microbiota and brainFrontiers in microbiology · 2023Review
- Reduced false positives in autism screening via digital biomarkers inferred from deep comorbidity patterns.Science advances · 2021Article
- A Healthy Gut for a Healthy Brain: Preclinical, Clinical and Regulatory Aspects.Current neuropharmacology · 2021Review
- Gluten-Free Casein-Free Diet for Autism Spectrum Disorders: Can It Be Effective in Solving Behavioural and Gastrointestinal Problems?The Eurasian journal of medicine · 2020Review
- Using genomic resources for linkage analysis in Peromyscus with an application for characterizing Dominant Spot.BMC genomics · 2020Article
- Cortical Gray Matter Injury in Encephalopathy of Prematurity: Link to Neurodevelopmental Disorders.Frontiers in neurology · 2020Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review considers a link between prematurity and autism by comparing symptoms, physiological abnormalities, and behavior. It focuses on the bidirectional signaling between the microbiota and the brain, here defined as the microbiota-gut-vagus-heart-brain (MGVHB) axis and its systemic disruption accompanying altered neurodevelopment. Data derived from clinical and animal studies document increased prevalence of gastrointestinal, cardiovascular, cognitive, and behavioral symptoms in both premature and autistic children and suggest an incomplete maturation of the gut-blood barrier resulting in a "leaky gut," dysbiosis, abnormalities in vagal regulation of the heart, altered development of specific brain regions, and behavior. Furthermore, this review posits the hypothesis that common genetic variants link the abnormalities in the MGVHB axis in premature and autistic pathologies. This hypothesis is based on the recently identified common genetic variants: early B cell factor 1 (EBF1), selenocysteine tRNA-specific eukaryotic elongation factor (EEFSEC), and angiotensin II receptor type 2 (AGTR2), in the maternal and infant DNA samples, associated with risk of preterm birth and independently implicated in a risk of autism. We predict that the AGTR2 variants involved in the brain maturation and oxytocin-arginine-vasopressin (OXT-AVP) pathways, related to social behavior, will contribute to our understanding of the link between prematurity and autism paving a way to new therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.