ArticleDigestive diseases and sciences2018
Survival Disparities by Race and Ethnicity in Early Esophageal Cancer.
Article in Digestive diseases and sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neoadjuvant chemoimmunotherapy for locally advanced esophageal squamous cell carcinoma: Data from literature review and a real-world analysis.Thoracic cancer · 2024Pooled it
- Association of Radiotherapy Duration With Clinical Outcomes in Patients With Esophageal Cancer Treated in NRG Oncology Trials: A Secondary Analysis of NRG Oncology Randomized Clinical Trials.JAMA network open · 2023Trial
- Racial and ethnic disparities in esophageal cancer survival are greatest at curable stages: a population-based study.Cancer causes & control : CCC · 2026Article
- Does robotic-assisted esophagectomy improve outcomes compared to other techniques? An NCDB analysis of access and disparities.Surgical endoscopy · 2026Article
- MicroRNA-155 and its exosomal form: Small pieces in the gastrointestinal cancers puzzle.Cell biology and toxicology · 2024Review
- Article
- Purine salvage-associated metabolites as biomarkers for early diagnosis of esophageal squamous cell carcinoma: a diagnostic model-based study.Cell death discovery · 2024Article
- TCGA Expression Analyses of 10 Carcinoma Types Reveal Clinically Significant Racial Differences.Cancers · 2023Article
- A novel web-based dynamic nomogram for recurrent laryngeal nerve lymph node metastasis in esophageal squamous cell carcinoma.Frontiers in surgery · 2022Article
- Epidemiology and Outcomes of Young-Onset Esophageal Adenocarcinoma: An Analysis from a Population-Based Database.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
- Changes in Racial Disparities in Mortality After Cancer Surgery in the US, 2007-2016.JAMA network open · 2020Article
- Racial and ethnic disparities in mortality from gastric and esophageal adenocarcinoma.Cancer medicine · 2020Article
- Prediction of Lymph Node Metastasis in Superficial Esophageal Cancer Using a Pattern Recognition Neural Network.Cancer management and research · 2020Article
- Nomogram predicting cancer-specific mortality in patients with esophageal adenocarcinoma: a competing risk analysis.Journal of thoracic disease · 2019Article
- The Four Horsemen in Colon Cancer.Journal of oncology · 2019Review
- Characteristics of early- versus late-onset esophageal adenocarcinoma: insights from the National Inpatient Sample 2016-2020.Annals of gastroenterologyArticle
- Clinical-morphological profiles of esophageal carcinoma's main types.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
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6 authors.
Funding
Abstract
backgroundSurvival outcome disparities among esophageal cancer patients exist, but are not fully understood.
aimsWe used the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database to determine whether survival differences among racial/ethnic patient populations persist after adjusting for demographic and clinical characteristics.
methodsOur study included T1-3N0M0 adenocarcinoma and squamous cell cancer patients diagnosed between 2003 and 2011. We compared survival among two racial/ethnic patient subgroups using Cox proportional hazards methods, adjusting for age, sex, histology, marital status, socioeconomics, SEER region, comorbidities, T stage, tumor location, diagnosis year, and treatment received.
resultsAmong 2025 patients, 87.9% were White and 12.1% were Nonwhite. Median survival was 18.7 months for Whites vs 13.8 months for Nonwhites (p = 0.01). In the unadjusted model, Nonwhite patients had higher risk of mortality (HR = 1.29, 95% CI 1.11-1.49, p < 0.0001) when compared to White patients; however, in the Cox regression adjusted model there was no significant difference (HR = 0.94, 95% CI 0.80-1.10, p = 0.44). Surgery, chemotherapy, younger age, lower T stage, and lower Charlson comorbidity score were significant predictors in the full adjusted model.
conclusionsDifferences in mortality risk by race/ethnicity appear to be largely explained by additional factors. In particular, associations were seen in surgery and T stage. Further research is needed to understand potential mechanisms underlying the differences and to better target patients who can benefit from treatment options.
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