Evidence map›Paper›PMID 30109466›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2018

Disease progression in Parkinson subtypes: the PPMI dataset.

Darko Aleksovski, Dragana Miljkovic, Daniele Bravi, Angelo Antonini

Abstract read
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.

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  2. BDNF Val66Met polymorphism and cognitive impairment in Parkinson's disease-a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Darko AleksovskiDepartment of Knowledge Technologies, Jozef Stefan Institute, Ljubljana, Slovenia.
Dragana MiljkovicDepartment of Knowledge Technologies, Jozef Stefan Institute, Ljubljana, Slovenia.
Daniele BraviLundbeck Research and Development, Copenhagen, Denmark.
Angelo AntoniniDepartment of Neuroscience, University of Padua, Padua, Italy. angelo3000@yahoo.com.ORCID http://orcid.org/0000-0003-1040-2807
Jožef Stefan Institute · SILundbeck (Denmark) · DKUniversity of Padua · IT

Funding

Horizon 2020 643706
6 · The paper itself

Abstract

introductionDiscrete patterns of progression have been suggested for patients with Parkinson disease and presenting tremor dominant (TD) or postural instability gait disorders (PIGD). However, longitudinal prospective assessments need to take into consideration the variability in clinical manifestations and the evidence that only 40% of initially classified PIGD remain in this subtype at subsequent visits.

methodsWe analyzed clinical progression of PIGD compared to TD using longitudinal clinical data from the PPMI. Given the reported instability of such clinical classification, we only included patients who were reported as PIGD/TD at each visit during the 4-year observation. We used linear mixed-effects models to test differences in progression in these subgroups in 51 dependent variables.

resultsThere were 254 patients with yearly assessment. The number of PIGD was 36/254 vs 144/254 TD. PIGD had more severe motor disease at baseline but progressed faster than TD only in three non-motor items of the MDS-UPDRS: cognitive impairment, hallucinations, and psychosis plus features of DDS. Our analysis also showed in PIGD faster increase in the average time with dyskinesia.

conclusionsPIGD are characterized by more severe disease manifestations at diagnosis and greater cognitive progression, more frequent hallucinations, psychosis as well as features of DDS than TD patients. We interpret these findings as expression of greater cortical and subcortical involvement in PIGD already at onset. Since PIGD/TD classification is very unstable at onset, our analysis based on stricter definition criteria provides important insight for clinical trial stratification and definition of related outcome measures.

Indexed as

AdultAgedCognition DisordersDatabases, FactualDisease ProgressionFemaleGait Disorders, NeurologicHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsNortropanesParkinson DiseasePsychiatric Status Rating ScalesSeverity of Illness IndexioflupaneNortropanesCognitionMotor fluctuationsParkinson diseasePIGDPPMIProgressionTremor

Identifiers

PMID30109466
OpenAlexW2887462902

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.