Evidence map›Paper›PMID 30109417›Full record

SynthesisParasitology research2018

Toxoplasma gondii infection and behavioral outcomes in humans: a systematic review.

Victor Otero Martinez, Fernanda Washington de Mendonça Lima, Chrissie Ferreira de Carvalho, José Antônio Menezes-Filho

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Parasitology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Oxadiargyl analogs as potent inhibitors ofRSC medicinal chemistry · 2026
    Article
  3. Article
  4. The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Article
  5. Article
  6. Prevalence ofParasite epidemiology and control · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Molecular Mimicry betweenBiomolecules · 2024
    Article
  12. Article
  13. In vitro anti-Archives of Razi Institute · 2024
    Article
  14. Risk Factors Associated withMicroorganisms · 2024
    Article
  15. Article
  16. Potent In Vitro and In Vivo Effects ofTropical medicine and infectious disease · 2023
    Article
  17. The role ofFrontiers in cellular and infection microbiology · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Victor Otero MartinezImmunology Service of Infectious Diseases, Faculty of Pharmacy, Federal University of Bahia, Rua Barão de Jeremoabo, 147, Ondina, Salvador, Bahia, 40170-115, Brazil.
Fernanda Washington de Mendonça LimaImmunology Service of Infectious Diseases, Faculty of Pharmacy, Federal University of Bahia, Rua Barão de Jeremoabo, 147, Ondina, Salvador, Bahia, 40170-115, Brazil. mlima@ufba.br.
Chrissie Ferreira de CarvalhoLaboratory of Interdisciplinary Research in Human Neurodevelopment, Catholic University of Salvador, Salvador, Bahia, Brazil.
José Antônio Menezes-FilhoLaboratory of Toxicology, Faculty of Pharmacy, Federal University of Bahia, Salvador, Bahia, Brazil.
Universidade Federal da Bahia · BRUniversidade Católica do Salvador · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies suggest that the protozoan Toxoplasma gondii can disturb human behavior. This study aimed to systematically review the scientific literature on the possible associations between Toxoplasma gondii infection and neurobehavioral abnormalities in humans. We reviewed and summarized the studies published since 1990. The descriptors used were related to T. gondii infection and behavioral outcomes in humans; the main databases of the medical literature were accessed. The results of eight original articles published between 1994 and 2016 were evaluated and described. The most common serological method was the enzyme immunoassay. Most of the researchers used validated instruments for behavioral evaluation. Seven studies reported some association between the prevalence of anti-T. gondii antibodies and some altered behavioral aspects in adult humans; these studies focused on adult population in Europe and the USA. The most reported behavioral deviations are related to greater impulsivity and aggressiveness. There are very few studies on this subject, which present some limitations for inference and conclusions: most were cross-sectional studies, with a small sample size and in similar populations. Investigations with a larger sample size of different population groups should be performed to evaluate multiple factors.

Indexed as

AdultAntibodies, ProtozoanEuropeFemaleHumansImmunoenzyme TechniquesImmunoglobulin GMaleMental DisordersNervous System DiseasesPersonality TestsPrevalenceSeroepidemiologic StudiesToxoplasmaToxoplasmosisAntibodies, ProtozoanImmunoglobulin GBehavior problemsNeurobehavioral manifestationsSeroprevalenceToxoplasma

Identifiers

PMID30109417
OpenAlexW2885660404

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.