Evidence map›Paper›PMID 30109373›Full record

ArticlePsychopharmacology2018

Cannabinoid receptor-1 signaling contributions to sign-tracking and conditioned reinforcement in rats.

Sam Z Bacharach, Helen M Nasser, Natalie E Zlebnik, Hannah M Dantrassy, Daniel E Kochli, Utsav Gyawali, Joseph F Cheer, Donna J Calu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

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  6. Decreased Ventral Tegmental Area CB1R Signaling Reduces Sign Tracking and Shifts Cue-Outcome Dynamics in Rat Nucleus Accumbens.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sam Z BacharachDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street - HSFII Room S263, Baltimore, MD, 21201, USA.
Helen M NasserDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street - HSFII Room S263, Baltimore, MD, 21201, USA.
Natalie E ZlebnikDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street - HSFII Room S263, Baltimore, MD, 21201, USA.
Hannah M DantrassyDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street - HSFII Room S263, Baltimore, MD, 21201, USA.
Daniel E KochliDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street - HSFII Room S263, Baltimore, MD, 21201, USA.
Utsav GyawaliDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street - HSFII Room S263, Baltimore, MD, 21201, USA.
Joseph F CheerDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street - HSFII Room S263, Baltimore, MD, 21201, USA.
Donna J CaluDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street - HSFII Room S263, Baltimore, MD, 21201, USA. dcalu@som.umaryland.edu.ORCID http://orcid.org/0000-0003-2377-9494
University of Maryland, Baltimore · US

Funding

Endogenous Cannabinoid Control of Reward SubstratesR01DA022340 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI Joseph F Cheer · 2008 to 2026
$5.6M
Role of basolateral amygdala projections in mediating individual differences in motivation and flexibilityR01DA043533 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI GOGERDCHI, DONNA CALU · 2017 to 2022
$2.3M
Enduring Consequences of Adolescent Cannabinoid and Methylphenidate ExposureR01DA042595 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI CHEER, JOSEPH F · 2016 to 2020
$2.0M
Endocannabinoid regulation of corticostriatal network activity in an animal model of cocaine relapseF32DA043967 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI ZLEBNIK, NATALIE · 2018 to 2019
$96k
Brain and Behavior Research Foundation 24950Evelyn F. McKnight Brain Research Foundation Memory and Cognitive Disorders AwardNational Institute on Drug Abuse R01DA022340National Institute on Drug Abuse R01DA042595National Institute on Drug Abuse R01DA043533NIDA NIH HHS F32 DA043967NIDA NIH HHS R01 DA022340NIDA NIH HHS R01 DA042595NIDA NIH HHS R01 DA043533University of Maryland School of Medicine Department of Anatomy and Neurobiology
6 · The paper itself

Abstract

rationaleEndocannabinoids (eCBs) are critical gatekeepers of dopaminergic signaling, and disrupting cannabinoid receptor-1 (CB1) signaling alters DA dynamics to attenuate cue-motivated behaviors. Prior studies suggest that dopamine (DA) release plays a critical role in driving sign-tracking.

objectivesHere, we determine whether systemic injections of rimonabant, a CB1 receptor inverse agonist, during Pavlovian lever autoshaping impair the expression of sign-tracking. We next examine whether rimonabant blocks the reinforcing properties of the Pavlovian lever cue in a conditioned reinforcement test.

methodsIn Exp. 1, we trained rats in Pavlovian lever autoshaping prior to systemic rimonabant injections (0, 1, 3 mg/kg) during early and late Pavlovian lever autoshaping sessions. In Exp. 2, we trained rats in Pavlovian lever autoshaping prior to systemic rimonabant injections (0, 1 mg/kg) during a conditioned reinforcement test.

resultsRimonabant dose-dependently decreased lever contact and probability, and increased sign-tracker's latency to approach the lever cue early in Pavlovian training. With extended training, many previously goal-tracking and intermediate rats shifted to lever approach, which remained dose-dependently sensitive to rimonabant. Rimonabant attenuated cue-evoked food cup approach early, but not late, in conditioning, and did not affect pellet retrieval or consumption. The inserted lever cue served as a robust conditioned reinforcer after Pavlovian lever autoshaping, and 1 mg/kg rimonabant blocked conditioned reinforcement.

conclusionsTogether, our results suggest that CB1 signaling mediates two critical properties of incentive stimuli; their ability to attract (Exp. 1) and their ability to reinforce (Exp. 2) behavior.

Indexed as

Reinforcement, PsychologyAnimalsConditioning, ClassicalCuesFeeding BehaviorMaleRatsRats, Sprague-DawleyReceptor, Cannabinoid, CB1RimonabantSignal TransductionReceptor, Cannabinoid, CB1RimonabantAppetitiveApproachCB1 receptorConditioned reinforcementCue-motivatedEndocannabinoidsIncentivePavlovianSign-tracking

Identifiers

PMID30109373
PMCPMC6344029
OpenAlexW2886415350

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.