Evidence map›Paper›PMID 30109265›Full record

ArticleNeurology. Genetics2018

Population genealogy resource shows evidence of familial clustering for Alzheimer disease.

Lisa Anne Cannon-Albright, Sue Dintelman, Tim Maness, Johni Cerny, Alun Thomas, Steven Backus, James Michael Farnham, Craig Carl Teerlink, Jorge Contreras, John S K Kauwe and 1 more

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Article in Neurology. Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lisa Anne Cannon-AlbrightGenetic Epidemiology Program (L.A.C.-A., A.T., S.B., J.M.F., C.C.T.), Department of Internal Medicine, University of Utah School of Medicine; George E. Wahlen Department of Veterans Affairs Medical Center (L.A.C.-A., L.J.M.); Pleiades Software Development (S.D., T.M.), Inc, Salt Lake City; Lineages (J.C.), Draper; SJ Quinney College of Law (J.C.), University of Utah; Department of Biology (J.S.K.K.), Brigham Young University, Provo; Department of Dermatology (L.J.M.), University of Utah School of Medicine, Salt Lake City; and Department of Veterans Affairs (L.J.M.), Washington DC.
Sue DintelmanGenetic Epidemiology Program (L.A.C.-A., A.T., S.B., J.M.F., C.C.T.), Department of Internal Medicine, University of Utah School of Medicine; George E. Wahlen Department of Veterans Affairs Medical Center (L.A.C.-A., L.J.M.); Pleiades Software Development (S.D., T.M.), Inc, Salt Lake City; Lineages (J.C.), Draper; SJ Quinney College of Law (J.C.), University of Utah; Department of Biology (J.S.K.K.), Brigham Young University, Provo; Department of Dermatology (L.J.M.), University of Utah School of Medicine, Salt Lake City; and Department of Veterans Affairs (L.J.M.), Washington DC.
Tim ManessGenetic Epidemiology Program (L.A.C.-A., A.T., S.B., J.M.F., C.C.T.), Department of Internal Medicine, University of Utah School of Medicine; George E. Wahlen Department of Veterans Affairs Medical Center (L.A.C.-A., L.J.M.); Pleiades Software Development (S.D., T.M.), Inc, Salt Lake City; Lineages (J.C.), Draper; SJ Quinney College of Law (J.C.), University of Utah; Department of Biology (J.S.K.K.), Brigham Young University, Provo; Department of Dermatology (L.J.M.), University of Utah School of Medicine, Salt Lake City; and Department of Veterans Affairs (L.J.M.), Washington DC.
Johni CernyGenetic Epidemiology Program (L.A.C.-A., A.T., S.B., J.M.F., C.C.T.), Department of Internal Medicine, University of Utah School of Medicine; George E. Wahlen Department of Veterans Affairs Medical Center (L.A.C.-A., L.J.M.); Pleiades Software Development (S.D., T.M.), Inc, Salt Lake City; Lineages (J.C.), Draper; SJ Quinney College of Law (J.C.), University of Utah; Department of Biology (J.S.K.K.), Brigham Young University, Provo; Department of Dermatology (L.J.M.), University of Utah School of Medicine, Salt Lake City; and Department of Veterans Affairs (L.J.M.), Washington DC.
Alun ThomasGenetic Epidemiology Program (L.A.C.-A., A.T., S.B., J.M.F., C.C.T.), Department of Internal Medicine, University of Utah School of Medicine; George E. Wahlen Department of Veterans Affairs Medical Center (L.A.C.-A., L.J.M.); Pleiades Software Development (S.D., T.M.), Inc, Salt Lake City; Lineages (J.C.), Draper; SJ Quinney College of Law (J.C.), University of Utah; Department of Biology (J.S.K.K.), Brigham Young University, Provo; Department of Dermatology (L.J.M.), University of Utah School of Medicine, Salt Lake City; and Department of Veterans Affairs (L.J.M.), Washington DC.
Steven BackusGenetic Epidemiology Program (L.A.C.-A., A.T., S.B., J.M.F., C.C.T.), Department of Internal Medicine, University of Utah School of Medicine; George E. Wahlen Department of Veterans Affairs Medical Center (L.A.C.-A., L.J.M.); Pleiades Software Development (S.D., T.M.), Inc, Salt Lake City; Lineages (J.C.), Draper; SJ Quinney College of Law (J.C.), University of Utah; Department of Biology (J.S.K.K.), Brigham Young University, Provo; Department of Dermatology (L.J.M.), University of Utah School of Medicine, Salt Lake City; and Department of Veterans Affairs (L.J.M.), Washington DC.
James Michael FarnhamGenetic Epidemiology Program (L.A.C.-A., A.T., S.B., J.M.F., C.C.T.), Department of Internal Medicine, University of Utah School of Medicine; George E. Wahlen Department of Veterans Affairs Medical Center (L.A.C.-A., L.J.M.); Pleiades Software Development (S.D., T.M.), Inc, Salt Lake City; Lineages (J.C.), Draper; SJ Quinney College of Law (J.C.), University of Utah; Department of Biology (J.S.K.K.), Brigham Young University, Provo; Department of Dermatology (L.J.M.), University of Utah School of Medicine, Salt Lake City; and Department of Veterans Affairs (L.J.M.), Washington DC.
Craig Carl TeerlinkGenetic Epidemiology Program (L.A.C.-A., A.T., S.B., J.M.F., C.C.T.), Department of Internal Medicine, University of Utah School of Medicine; George E. Wahlen Department of Veterans Affairs Medical Center (L.A.C.-A., L.J.M.); Pleiades Software Development (S.D., T.M.), Inc, Salt Lake City; Lineages (J.C.), Draper; SJ Quinney College of Law (J.C.), University of Utah; Department of Biology (J.S.K.K.), Brigham Young University, Provo; Department of Dermatology (L.J.M.), University of Utah School of Medicine, Salt Lake City; and Department of Veterans Affairs (L.J.M.), Washington DC.
Jorge ContrerasGenetic Epidemiology Program (L.A.C.-A., A.T., S.B., J.M.F., C.C.T.), Department of Internal Medicine, University of Utah School of Medicine; George E. Wahlen Department of Veterans Affairs Medical Center (L.A.C.-A., L.J.M.); Pleiades Software Development (S.D., T.M.), Inc, Salt Lake City; Lineages (J.C.), Draper; SJ Quinney College of Law (J.C.), University of Utah; Department of Biology (J.S.K.K.), Brigham Young University, Provo; Department of Dermatology (L.J.M.), University of Utah School of Medicine, Salt Lake City; and Department of Veterans Affairs (L.J.M.), Washington DC.
John S K KauweGenetic Epidemiology Program (L.A.C.-A., A.T., S.B., J.M.F., C.C.T.), Department of Internal Medicine, University of Utah School of Medicine; George E. Wahlen Department of Veterans Affairs Medical Center (L.A.C.-A., L.J.M.); Pleiades Software Development (S.D., T.M.), Inc, Salt Lake City; Lineages (J.C.), Draper; SJ Quinney College of Law (J.C.), University of Utah; Department of Biology (J.S.K.K.), Brigham Young University, Provo; Department of Dermatology (L.J.M.), University of Utah School of Medicine, Salt Lake City; and Department of Veterans Affairs (L.J.M.), Washington DC.
Laurence J MeyerGenetic Epidemiology Program (L.A.C.-A., A.T., S.B., J.M.F., C.C.T.), Department of Internal Medicine, University of Utah School of Medicine; George E. Wahlen Department of Veterans Affairs Medical Center (L.A.C.-A., L.J.M.); Pleiades Software Development (S.D., T.M.), Inc, Salt Lake City; Lineages (J.C.), Draper; SJ Quinney College of Law (J.C.), University of Utah; Department of Biology (J.S.K.K.), Brigham Young University, Provo; Department of Dermatology (L.J.M.), University of Utah School of Medicine, Salt Lake City; and Department of Veterans Affairs (L.J.M.), Washington DC.

Funding

Epidemiology of Alzheimer’s disease resilience and risk pedigreesRF1AG054052 · NIA · BRIGHAM YOUNG UNIVERSITY · PI KAUWE, JOHN SAI KEONG · 2016 to 2020
$3.6M
NIA NIH HHS RF1 AG054052
6 · The paper itself

Abstract

objectiveTo show the potential of a resource consisting of a genealogy of the US record linked to National Veterans Health Administration (VHA) patient data for investigation of the genetic contribution to health-related phenotypes, we present an analysis of familial clustering of VHA patients diagnosed with Alzheimer disease (AD).

methodsPatients with AD were identified by the

resultsEvidence for significant excess relatedness and significantly elevated risks for AD in relatives was observed; multiple pedigrees with a significant excess of VHA patients with AD were identified.

conclusionsThis analysis of AD shows the nascent power of the US Veterans Genealogy Resource, in early stages, to provide evidence for familial clustering of multiple phenotypes, and shows the utility of this VHA genealogic resource for future genetic studies.

Identifiers

PMID30109265
PMCPMC6089693

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