ArticleActa pharmaceutica Sinica. B2018
Biocatalytic access to diverse prenylflavonoids by combining a regiospecific
Article in Acta pharmaceutica Sinica. B, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- An aromatic substrate prenyltransferase involved in the chemical diversification of flavonoids in Glycyrrhiza glabra.Planta · 2026Article
- A FungalJournal of agricultural and food chemistry · 2026Article
- Tuning aromatic cage occupancy in prenyltransferases enables selective and efficient production of rare c-prenylated flavonoids.Nature communications · 2026Article
- De novo biosynthesis of the hops bioactive flavonoid xanthohumol in yeast.Nature communications · 2024Article
- Heterologous biosynthesis of isobavachalcone in tobacco based onFrontiers in plant science · 2022Article
- Article
- Quantification of One Prenylated Flavanone fromBiomolecules · 2020Article
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7 authors.
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Abstract
Prenylflavonoids are valuable natural products that have diverse biological properties, and are usually generated biologically by multiple metabolic enzymes in nature. In this study, structurally diverse prenylflavonoids were conveniently synthesized by enzymatic catalysis by combining GuILDT, a regiospecific chalcone prenyltransferase, and GuCHI, a stereospecific chalcone isomerase that has promiscuous activity for both chalcones and prenylchalcones as substrates. Our findings provided a new approach for the synthesis of natural/unnatural bioactive prenylflavonoids, including prenylchalcones and optical prenylflavanones with chalcone origins.
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