Evidence map›Paper›PMID 30109132›Full record

ArticleEnvironmental epigenetics2018

Pre-reproductive stress and fluoxetine treatment in rats affect offspring A-to-I RNA editing, gene expression and social behavior.

Hiba Zaidan, Gokul Ramaswami, Michal Barak, Jin B Li, Inna Gaisler-Salomon

Open access · goldAbstract read
In one paragraph

Article in Environmental epigenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  3. Review
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  5. Article
  6. Review
  7. Article
  8. Gestational Factors throughout Fetal Neurodevelopment: The Serotonin Link.International journal of molecular sciences · 2020
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Hiba ZaidanDepartment of Psychology, University of Haifa, Haifa, Israel.
Gokul RamaswamiDepartment of Genetics, Stanford University, Stanford, CA, USA.
Michal BarakThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
Jin B LiDepartment of Genetics, Stanford University, Stanford, CA, USA.
Inna Gaisler-SalomonDepartment of Psychology, University of Haifa, Haifa, Israel.ORCID 0000-0002-7498-3949
University of Haifa · ILBar-Ilan University · ILStanford University · USUniversity of California, Los Angeles · US

Funding

Profiling and Dissecting the Dynamic Regulation of RNA EditingR01GM102484 · NIGMS · STANFORD UNIVERSITY · PI LI, JIN BILLY · 2013 to 2021
$3.1M
NIGMS NIH HHS R01 GM102484
6 · The paper itself

Abstract

Adenosine to inosine RNA editing is an epigenetic process that entails site-specific modifications in double-stranded RNA molecules, catalyzed by adenosine deaminases acting on RNA (ADARs). Using the multiplex microfluidic PCR and deep sequencing technique, we recently showed that exposing adolescent female rats to chronic unpredictable stress before reproduction affects editing in the prefrontal cortex and amygdala of their newborn offspring, particularly at the serotonin receptor 5-HT2c (encoded by

Indexed as

fluoxetineHtr2cintergenerationalratRNA editingstress

Identifiers

PMID30109132
PMCPMC6084559
OpenAlexW2885970262

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.