Evidence map›Paper›PMID 30108906›Full record

ArticleMedChemComm2018

Novel cell-penetrating-amyloid peptide conjugates preferentially kill cancer cells.

John R Veloria, Luxi Chen, Lin Li, Gail A M Breen, Jiyong Lee, Warren J Goux

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedChemComm, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

John R VeloriaDepartment of Biological Sciences , The University of Texas at Dallas , 800 W. Campbell Rd , Richardson , TX 75080 , USA.ORCID 0000-0003-2024-2245
Luxi ChenDepartment of Chemistry and Biochemistry , The University of Texas at Dallas , 800 W. Campbell Rd , Richardson , TX 75080 , USA . Email: wgoux@utdallas.edu.
Lin LiDepartment of Biological Sciences , The University of Texas at Dallas , 800 W. Campbell Rd , Richardson , TX 75080 , USA.
Gail A M BreenDepartment of Biological Sciences , The University of Texas at Dallas , 800 W. Campbell Rd , Richardson , TX 75080 , USA.
Jiyong LeeDepartment of Chemistry and Biochemistry , The University of Texas at Dallas , 800 W. Campbell Rd , Richardson , TX 75080 , USA . Email: wgoux@utdallas.edu.
Warren J GouxDepartment of Chemistry and Biochemistry , The University of Texas at Dallas , 800 W. Campbell Rd , Richardson , TX 75080 , USA . Email: wgoux@utdallas.edu.ORCID 0000-0002-3697-6289
The University of Texas at Dallas · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The goal of this study was to develop a peptide which could use the toxic effects of amyloid, a substance which is the hallmark of over 25 known human diseases, to selectively kill cancer cells. Here we demonstrate that two separate amyloid-forming hexapeptides, one from the microtubule associated protein Tau involved in formation of paired helical filaments of Alzheimer's disease, and the other an amyloid forming sequence from apolipoprotein A

Identifiers

PMID30108906
PMCPMC6071918
OpenAlexW2774407838

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.