Evidence map›Paper›PMID 30108890›Full record

ArticleMedChemComm2017

Structure-optimized dihydropyranoindole derivative GIBH-LRA002 potentially reactivated viral latency in primary CD4+ T lymphocytes of chronic HIV-1 patients.

Qing Yang, Yuyang Ding, Fengling Feng, Enxiang Pan, Xiaozhen Fan, Xiuchang Ma, Ling Chen, Junling Zhao, Caijun Sun

Abstract read
In one paragraph

Article in MedChemComm, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qing YangGuangzhou Institutes of Biomedicine and Health (GIBH) , Chinese Academy of Sciences , Guangzhou 510530 , China . Email: Sun_caijun@gibh.ac.cn.
Yuyang DingGuangzhou Institutes of Biomedicine and Health (GIBH) , Chinese Academy of Sciences , Guangzhou 510530 , China . Email: Sun_caijun@gibh.ac.cn.
Fengling FengGuangzhou Institutes of Biomedicine and Health (GIBH) , Chinese Academy of Sciences , Guangzhou 510530 , China . Email: Sun_caijun@gibh.ac.cn.
Enxiang PanGuangzhou Institutes of Biomedicine and Health (GIBH) , Chinese Academy of Sciences , Guangzhou 510530 , China . Email: Sun_caijun@gibh.ac.cn.
Xiaozhen FanGuangzhou Institutes of Biomedicine and Health (GIBH) , Chinese Academy of Sciences , Guangzhou 510530 , China . Email: Sun_caijun@gibh.ac.cn.
Xiuchang MaGuangzhou Institutes of Biomedicine and Health (GIBH) , Chinese Academy of Sciences , Guangzhou 510530 , China . Email: Sun_caijun@gibh.ac.cn.
Ling ChenGuangzhou Institutes of Biomedicine and Health (GIBH) , Chinese Academy of Sciences , Guangzhou 510530 , China . Email: Sun_caijun@gibh.ac.cn.
Junling ZhaoInstitute of Medicinal Chemistry , School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou 510006 , P.R. China . Email: zhaojunl@iccas.ac.cn.
Caijun SunGuangzhou Institutes of Biomedicine and Health (GIBH) , Chinese Academy of Sciences , Guangzhou 510530 , China . Email: Sun_caijun@gibh.ac.cn.ORCID 0000-0002-2000-7053

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Based on structure modification and a high-throughput Jurkat-Lat cell screening model, we found that GIBH-LRA002, ethyl-2-amino-3-cyano-9-methyl-4-(trifluoromethyl)-4,9-dihydropyrano[2,3-

Identifiers

PMID30108890
PMCPMC6084221

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.