Evidence map›Paper›PMID 30108877›Full record

ArticleMedChemComm2017

Environment-sensitive turn-on fluorescent probes for p53-MDM2 protein-protein interaction.

Tingting Liu, Yan Jiang, Zhenzhen Liu, Jin Li, Kun Fang, Chunlin Zhuang, Lupei Du, Hao Fang, Chunquan Sheng, Minyong Li

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in MedChemComm, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Tingting LiuDepartment of Medicinal Chemistry , Key Laboratory of Chemical Biology (MOE) , School of Pharmacy , Shandong University , Jinan , Shandong 250012 , China . Email: mli@sdu.edu.cn.
Yan JiangDepartment of Medicinal Chemistry , School of Pharmacy , Second Military Medical University , 325 Guohe Road , Shanghai 200433 , China . Email: shengcq@hotmail.com.
Zhenzhen LiuDepartment of Medicinal Chemistry , Key Laboratory of Chemical Biology (MOE) , School of Pharmacy , Shandong University , Jinan , Shandong 250012 , China . Email: mli@sdu.edu.cn.
Jin LiDepartment of Medicinal Chemistry , School of Pharmacy , Second Military Medical University , 325 Guohe Road , Shanghai 200433 , China . Email: shengcq@hotmail.com.
Kun FangDepartment of Medicinal Chemistry , School of Pharmacy , Second Military Medical University , 325 Guohe Road , Shanghai 200433 , China . Email: shengcq@hotmail.com.
Chunlin ZhuangDepartment of Medicinal Chemistry , School of Pharmacy , Second Military Medical University , 325 Guohe Road , Shanghai 200433 , China . Email: shengcq@hotmail.com.
Lupei DuDepartment of Medicinal Chemistry , Key Laboratory of Chemical Biology (MOE) , School of Pharmacy , Shandong University , Jinan , Shandong 250012 , China . Email: mli@sdu.edu.cn.
Hao FangDepartment of Medicinal Chemistry , Key Laboratory of Chemical Biology (MOE) , School of Pharmacy , Shandong University , Jinan , Shandong 250012 , China . Email: mli@sdu.edu.cn.
Chunquan ShengDepartment of Medicinal Chemistry , School of Pharmacy , Second Military Medical University , 325 Guohe Road , Shanghai 200433 , China . Email: shengcq@hotmail.com.
Minyong LiDepartment of Medicinal Chemistry , Key Laboratory of Chemical Biology (MOE) , School of Pharmacy , Shandong University , Jinan , Shandong 250012 , China . Email: mli@sdu.edu.cn.ORCID 0000-0003-3276-4921
Second Military Medical University · CNShandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of probes with a turn-on switch for the p53-MDM2 protein-protein interaction were developed. After careful evaluation, these small molecule fluorescent probes exhibited high practical activity and selectivity

Identifiers

PMID30108877
PMCPMC6072338
OpenAlexW2731231330

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.