Evidence map›Paper›PMID 30108874›Full record

ArticleMedChemComm2017

Discovery of potential antifungal triazoles: design, synthesis, biological evaluation, and preliminary antifungal mechanism exploration.

Yuan Zhang, Guri L V Damu, Sheng-Feng Cui, Jia-Li Mi, Vijai Kumar Reddy Tangadanchu, Cheng-He Zhou

Open access · bronzeAbstract read
In one paragraph

Article in MedChemComm, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Anti-Metabolites · 2022
    Article
  6. Molecules (Basel, Switzerland) · 2022
    Article
  7. Article
  8. Novel 1, 2, 4-Triazoles as Antifungal Agents.BioMed research international · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Yuan ZhangInstitute of Bioorganic & Medicinal Chemistry , Key Laboratory of Applied Chemistry of Chongqing Municipality , School of Chemistry and Chemical Engineering , Southwest University , Chongqing 400715 , PR China . Email: zhouch@swu.edu.cn ; ; Tel: +86 23 68254967.
Guri L V DamuInstitute of Bioorganic & Medicinal Chemistry , Key Laboratory of Applied Chemistry of Chongqing Municipality , School of Chemistry and Chemical Engineering , Southwest University , Chongqing 400715 , PR China . Email: zhouch@swu.edu.cn ; ; Tel: +86 23 68254967.
Sheng-Feng CuiInstitute of Bioorganic & Medicinal Chemistry , Key Laboratory of Applied Chemistry of Chongqing Municipality , School of Chemistry and Chemical Engineering , Southwest University , Chongqing 400715 , PR China . Email: zhouch@swu.edu.cn ; ; Tel: +86 23 68254967.
Jia-Li MiPeople's Hospital of Suining , Sichuan 629000 , PR China.
Vijai Kumar Reddy TangadanchuInstitute of Bioorganic & Medicinal Chemistry , Key Laboratory of Applied Chemistry of Chongqing Municipality , School of Chemistry and Chemical Engineering , Southwest University , Chongqing 400715 , PR China . Email: zhouch@swu.edu.cn ; ; Tel: +86 23 68254967.
Cheng-He ZhouInstitute of Bioorganic & Medicinal Chemistry , Key Laboratory of Applied Chemistry of Chongqing Municipality , School of Chemistry and Chemical Engineering , Southwest University , Chongqing 400715 , PR China . Email: zhouch@swu.edu.cn ; ; Tel: +86 23 68254967.ORCID 0000-0003-3233-5465
Southwest University · CNSuizhou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of triazoles as miconazole analogues was designed, synthesized and characterized by IR, NMR, MS and HRMS. All the newly prepared compounds were screened for their antifungal activities against five kinds of fungi. The bioactive assay showed that most of the synthesized compounds exhibited good or even stronger antifungal activities in comparison with the reference drugs miconazole and fluconazole. In particular, the 3,4-dichlorobenzyl derivative

Identifiers

PMID30108874
PMCPMC6071786
OpenAlexW2626993113

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.