ArticleMedChemComm2017
Exploring the links between peptoid antibacterial activity and toxicity.
Article in MedChemComm, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Recent progress in the structure-activity relationship of antibacterial peptoids.RSC advances · 2026Review
- Article
- Systematic Investigation on Acid-Catalyzed Truncation ofInternational journal of molecular sciences · 2024Article
- Antimicrobial Peptide-Peptoid Hybrids with and without Membrane Disruption.ACS infectious diseases · 2023Article
- The Antimicrobial, Antibiofilm and Anti-Inflammatory Activities of P13#1, a Cathelicidin-like Achiral Peptoid.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Late-Stage Chloride Displacements Enable Access to Peptoids withOrganic letters · 2023Article
- Article
- Natural and Synthetic Halogenated Amino Acids-Structural and Bioactive Features in Antimicrobial Peptides and Peptidomimetics.Molecules (Basel, Switzerland) · 2021Review
- Peptoids with Antibiofilm Activity against the Gram Negative Obligate Anaerobe,Molecules (Basel, Switzerland) · 2021Article
- Structural Diversity of Peptoids: Tube-Like Structures of Macrocycles.Molecules (Basel, Switzerland) · 2020Article
- Antimicrobial peptides - Advances in development of therapeutic applications.Life sciences · 2020Review
- Halogenation as a tool to tune antimicrobial activity of peptoids.Scientific reports · 2020Article
- Ultra-Short Antimicrobial Peptoids Show Propensity for Membrane Activity Against Multi-Drug ResistantFrontiers in microbiology · 2020Article
- Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response.Frontiers in immunology · 2020Review
- Peptide/Peptoid Hybrid Oligomers: The Influence of Hydrophobicity and Relative Side-Chain Length on Antibacterial Activity and Cell Selectivity.Molecules (Basel, Switzerland) · 2019Article
- Peptoid drug discovery and optimization via surface X-ray scattering.Biopolymers · 2019Review
- Toward a clinical antifungal peptoid: Investigations into the therapeutic potential of AEC5.Biopolymers · 2019Article
- Structure⁻Activity Study, Characterization, and Mechanism of Action of an Antimicrobial Peptoid D2 and Its d- and l-Peptide Analogues.Molecules (Basel, Switzerland) · 2019Article
- The Antimicrobial Peptide lin-SB056-1 and Its Dendrimeric Derivative PreventFrontiers in microbiology · 2019Article
- Improved potency and reduced toxicity of the antifungal peptoid AEC5 through submonomer modification.Bioorganic & medicinal chemistry letters · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peptoids are a promising class of antimicrobial agents with reported activities against a range of both Gram-positive and Gram-negative bacteria, fungi and most recently parasites. However, at present the available toxicity data is somewhat limited and as such rationally designing effective antimicrobial peptoids can be challenging. Herein, we present the toxicity profiling of a series of linear peptoids against mammalian cell lines (HaCaT and HepG2). The cytotoxicity of the peptoid library has then been correlated with their antibacterial properties against Gram-positive and Gram-negative bacteria and also to the hydrophobicity of the peptoid sequences. The work presented provides valuable data to aid in the future rational design of antimicrobial peptoids.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.