Evidence map›Paper›PMID 30108793›Full record

ArticleMedChemComm2017

Discovery and hit-to-lead evaluation of piperazine amides as selective, state-dependent Na

Brian A Sparling, S Yi, J Able, H Bregman, Erin F DiMauro, R S Foti, H Gao, A Guzman-Perez, H Huang, M Jarosh and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedChemComm, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Inhibition of NaRSC medicinal chemistry · 2022
    Review
  2. Spontaneous conversion ofRoyal Society open science · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Brian A SparlingDepartment of Medicinal Chemistry , Amgen Inc. , 360 Binney Street , Cambridge , MA 02142 , USA . Email: brian.sparling@amgen.com.ORCID 0000-0001-5184-0956
S YiDepartment of Medicinal Chemistry , Amgen Inc. , 360 Binney Street , Cambridge , MA 02142 , USA . Email: brian.sparling@amgen.com.
J AbleDepartment of Neuroscience , Amgen Inc. , One Amgen Center Drive , Thousand Oaks , CA 91320 , USA.
H BregmanDepartment of Medicinal Chemistry , Amgen Inc. , 360 Binney Street , Cambridge , MA 02142 , USA . Email: brian.sparling@amgen.com.
Erin F DiMauroDepartment of Medicinal Chemistry , Amgen Inc. , 360 Binney Street , Cambridge , MA 02142 , USA . Email: brian.sparling@amgen.com.
R S FotiDepartment of Pharmacokinetics and Drug Metabolism , Amgen Inc. , 360 Binney Street , Cambridge , MA 02142 , USA.
H GaoDepartment of Molecular Engineering, Amgen Inc. , 360 Binney Street , Cambridge , MA 02142 , USA.
A Guzman-PerezDepartment of Medicinal Chemistry , Amgen Inc. , 360 Binney Street , Cambridge , MA 02142 , USA . Email: brian.sparling@amgen.com.
H HuangDepartment of Medicinal Chemistry , Amgen Inc. , 360 Binney Street , Cambridge , MA 02142 , USA . Email: brian.sparling@amgen.com.
M JaroshDepartment of Neuroscience , Amgen Inc. , 360 Binney Street , Cambridge , MA 02142 , USA.
T KornecookDepartment of Neuroscience , Amgen Inc. , One Amgen Center Drive , Thousand Oaks , CA 91320 , USA.
J LiguttiDepartment of Neuroscience , Amgen Inc. , One Amgen Center Drive , Thousand Oaks , CA 91320 , USA.
B C MilgramDepartment of Medicinal Chemistry , Amgen Inc. , 360 Binney Street , Cambridge , MA 02142 , USA . Email: brian.sparling@amgen.com.
B D MoyerDepartment of Neuroscience , Amgen Inc. , One Amgen Center Drive , Thousand Oaks , CA 91320 , USA.
B YoungbloodDepartment of Neuroscience , Amgen Inc. , One Amgen Center Drive , Thousand Oaks , CA 91320 , USA.
V L YuDepartment of Neuroscience , Amgen Inc. , 360 Binney Street , Cambridge , MA 02142 , USA.
M M WeissDepartment of Medicinal Chemistry , Amgen Inc. , 360 Binney Street , Cambridge , MA 02142 , USA . Email: brian.sparling@amgen.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Na

Identifiers

PMID30108793
PMCPMC6072352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.