Evidence map›Paper›PMID 30108706›Full record

ArticleMedChemComm2017

Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination.

Renee Sokias, Eryn L Werry, Sook W Chua, Tristan A Reekie, Lenka Munoz, Erick C N Wong, Lars M Ittner, Michael Kassiou

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedChemComm, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Development and evaluation of [European journal of nuclear medicine and molecular imaging · 2025
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  4. Radiosynthesis of (R,S)-[ChemMedChem · 2019
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  5. Theranostics · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Renee SokiasSchool of Chemistry , The University of Sydney , NSW 2006 , Australia . Email: michael.kassiou@sydney.edu.au.
Eryn L WerryFaculty of Health Sciences , The University of Sydney , NSW 2006 , Australia.
Sook W ChuaDementia Research Unit , School of Medical Sciences , University of New South Wales , NSW 2052 , Australia.
Tristan A ReekieSchool of Chemistry , The University of Sydney , NSW 2006 , Australia . Email: michael.kassiou@sydney.edu.au.
Lenka MunozSchool of Medical Sciences (Pathology) and Charles Perkins Centre , The University of Sydney , NSW 2006 , Australia.
Erick C N WongSchool of Medical Sciences (Pharmacology) , Bosch Institute , The University of Sydney , NSW 2006 , Australia.
Lars M IttnerDementia Research Unit , School of Medical Sciences , University of New South Wales , NSW 2052 , Australia.
Michael KassiouSchool of Chemistry , The University of Sydney , NSW 2006 , Australia . Email: michael.kassiou@sydney.edu.au.
University of Sydney · AUUNSW Sydney · AURobert Bosch (India) · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 18 kDa translocator protein (TSPO) is a target for development of diagnostic imaging agents for glioblastoma and neuroinflammation. Clinical translation of TSPO imaging agents has been hindered by the presence of a polymorphism, rs6971, which causes a non-conservative substitution of alanine for threonine at amino acid residue 147 (TSPO A147T). Disclosed brain-permeant second-generation TSPO ligands bind TSPO A147T with reduced affinity compared to the wild type protein (TSPO WT). Efforts to develop a TSPO ligand that binds TSPO WT and TSPO A147T with similarly high affinity have been hampered by a lack of knowledge about how ligand structure differentially influences interaction with the two forms of TSPO. To gain insight, we have established human embryonic kidney cell lines stably over-expressing human TSPO WT and TSPO A147T, and tested how modifications of a novel

Identifiers

PMID30108706
PMCPMC6071920
OpenAlexW2554461375

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.