ArticleSaudi journal of biological sciences2018
Early-life gut microbiome and cow's milk allergy- a prospective case - control 6-month follow-up study.
Article in Saudi journal of biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Microbiota Signatures in Early Life and Their Association With Food Allergy: A Systematic Review.Allergy · 2026Pooled it
- GUT MICROBIOTA IN INFANTS WITH COW MILK ALLERGY: A SYSTEMATIC REVIEW OF CONTROLLED STUDIES.Arquivos de gastroenterologia · 2026Pooled it
- Probiotics supplementation during pregnancy or infancy on multiple food allergies and gut microbiota: a systematic review and meta-analysis.Nutrition reviews · 2025Pooled it
- Microbiological and Immunological Markers in Milk and Infant Feces for Common Gastrointestinal Disorders: A Pilot Study.Nutrients · 2020Trial
- Disentangling Gut Microbiome Alterations in Children with Cow's Milk Allergy: Impact of Sex, Milk Elimination, and Family History of Allergies.Nutrients · 2026Article
- Clinical Proteomics Applied to Food Allergy.Advances in experimental medicine and biology · 2026Review
- Diagnosis and Management of Food Protein-Induced Allergic Proctocolitis.Current gastroenterology reports · 2025Review
- Review
- Gut Microbiota Differences in Infants with Cow-Milk-Induced Allergic Proctocolitis: A Comparative Cross-Sectional Study.Children (Basel, Switzerland) · 2025Article
- Research Progress on Probiotics in Alleviating Cow's Milk Allergy: A Review.Foods (Basel, Switzerland) · 2025Review
- Bibliometric Analysis of Global Pediatric Research on Cow's Milk Protein Allergy.Journal of asthma and allergy · 2025Article
- Article
- Food Allergy Risk: A Comprehensive Review of Maternal Interventions for Food Allergy Prevention.Nutrients · 2024Review
- Characteristics of the Gut Microbiota in Regard to Atopic Dermatitis and Food Allergies of Children.Biomedicines · 2024Article
- Review
- Impact of ovalbumin allergy on oral and gut microbiome dynamics in 6-week-old BALB/c mice.Frontiers in microbiology · 2024Article
- Gut microbiome features in pediatric food allergy: a scoping review.Frontiers in allergy · 2024Article
- Allergy-associated biomarkers in early life identified by Omics techniques.Frontiers in allergy · 2024Review
- Body Composition Evaluation and Clinical Markers of Cardiometabolic Risk in Patients with Phenylketonuria.Nutrients · 2023Review
- Gut microbiome is associated with asthma and race in children with food allergy.The Journal of allergy and clinical immunology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing evidence suggests that perturbations in the intestinal microbiota in early infancy are implicated in the pathogenesis of food allergy (FA); existing evidence on the structure and composition of the intestinal microbiota in human beings with FA is limited and conflicting. The main object of the study was to compare the faecal microbiota between healthy and cow's milk allergy (CMA) infants at the baseline immediately after the diagnosis, and to evaluate the changes in the faecal microbiota after 6 months of treatment of CMA infants with hypoallergenic formula (HF), compared with healthy children fed on standard milk formulae. Sixty infants younger than 4 months of age with challenge-proven CMA and 60 healthy age-matched children were investigated in this prospective case - control follow-up study. Faecal samples were collected at baseline and at 6 months of follow-up, microbial diversity and composition were characterized by high-throughput 16S rRNA sequencing. The average age (±SD) of the infants at inclusion was 2.9 ± 1.0 months. Children with CMA have lower gut microbiota diversity and an elevated Enterobacteriaceae to Bacteroidaceae (E/B ratio) in early infancy compared with healthy children (115.8 vs. 0.8, P = 0.0002). After 6 months of treatment with HF, CMA infants had a higher Lactobacillaceae (6.3% vs. 0.5%, P = 0.04) and lower Bifidobacteriaceae (0.3% vs. 8.2%, P = 0.03) and Ruminococcaceae (1.5% vs. 10.5%, P = 0.03) abundance compared with control children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.