ArticleMolecular psychiatry2020
Distinct brain structure and behavior related to ADHD and conduct disorder traits.
Article in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- A meta-analysis of genetic effects associated with neurodevelopmental disorders and co-occurring conditions.Nature human behaviour · 2023Pooled it
- The IMAGEN study: a decade of imaging genetics in adolescents.Molecular psychiatry · 2020Pooled it
- Reward sensitivity is negatively associated with future self-continuity: the mediation role of functional connectivity between the dorsomedial prefrontal cortex and ventrolateral prefrontal cortex.Brain structure & function · 2026Article
- Executive functions as a transdiagnostic endophenotype in developmental psychopathology.Molecular psychiatry · 2026Review
- Neuropsychiatric outcomes after montelukast versus inhaled corticosteroids in pediatric asthma: a pooled birth cohort study.BMC medicine · 2026Article
- Associations between ADHD Symptoms and Psychiatric Symptoms in Children: Effects of Functional Impairment and Temperament.Journal of attention disorders · 2026Article
- ADHD, Subtypes and Cognitive Performance: WISC-V as a Support Tool for Diagnostic Assessment.Actas espanolas de psiquiatria · 2026Article
- Hypothalamus volumes and mental health in children and adolescents.Frontiers in neuroscience · 2026Article
- Specific frontostriatal structural alterations underlie emotional instability but not inattention in ADHD and healthy individuals.Journal of psychiatry & neuroscience : JPN · 2026Article
- Revisiting the Role of Serotonin in Attention-Deficit Hyperactivity Disorder: New Insights from Preclinical and Clinical Studies.Clinical drug investigation · 2025Review
- Cognitive Profiling of Children and Adolescents with ADHD Using the WISC-IV.Behavioral sciences (Basel, Switzerland) · 2025Article
- Insights into structural deviations in attention deficit hyperactivity disorder (ADHD) and comorbidities using big data-derived brain charts: a cross-sectional study.Quantitative imaging in medicine and surgery · 2025Article
- Beyond out-of-sample: robust and generalizable multivariate neuroanatomical patterns of psychiatric problems in youth.Molecular psychiatry · 2025Article
- Interpretable and integrative deep learning for discovering brain-behaviour associations.Scientific reports · 2025Article
- Editorial: Executive functions in psychiatric science, clinical practice and beyond: A Transdiagnostic Window on Functional Heterogeneity.Frontiers in psychiatry · 2025Article
- Associations of alcohol and tobacco use with psychotic, depressive and developmental disorders revealed via multimodal neuroimaging.Translational psychiatry · 2024Article
- The neural and genetic underpinnings of different developmental trajectories of Attention-Deficit/Hyperactivity Symptoms in children and adolescents.BMC medicine · 2024Article
- Deficits in emotional cognition among individuals with conduct disorder: theoretical perspectives.Frontiers in psychiatry · 2024Review
- Cognitive flexibility is associated with sickness resilience.Frontiers in psychology · 2024Article
- Bridging the Divide: Brain and Behavior in Developmental Language Disorder.Brain sciences · 2023Review
Corrections and comments
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Authors and funding
38 authors at 19 institutions in 8 countries.
Funding
Abstract
Attention-Deficit/Hyperactivity Disorder (ADHD) and conduct disorder (CD) exemplify top-down dysregulation conditions that show a large comorbidity and shared genetics. At the same time, they entail two different types of symptomology involving mainly non-emotional or emotional dysregulation. Few studies have tried to separate the specific biology underlying these two dimensions. It has also been suggested that both types of conditions consist of extreme cases in the general population where the symptoms are widely distributed. Here we test whether brain structure is specifically associated to ADHD or CD symptoms in a general population of adolescents (n = 1093) being part of the IMAGEN project. Both ADHD symptoms and CD symptoms were related to similar and overlapping MRI findings of a smaller structure in prefrontal and anterior cingulate cortex. However, our regions of interest (ROI) approach indicated that gray matter volume (GMV) and surface area (SA) in dorsolateral/dorsomedial prefrontal cortex and caudal anterior cingulate cortex were negatively associated to ADHD symptoms when controlling for CD symptoms while rostral anterior cingulate cortex GMV was negatively associated to CD symptoms when controlling for ADHD symptoms. The structural findings were mirrored in performance of neuropsychological tests dependent on prefrontal and anterior cingulate regions, showing that while performance on the Stop Signal test was specifically related to the ADHD trait, delayed discounting and working memory were related to both ADHD and CD traits. These results point towards a partially domain specific and dimensional capacity in different top-down regulatory systems associated with ADHD and CD symptoms.
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