ArticleScientific reports2018
The induction of the fibroblast extracellular senescence metabolome is a dynamic process.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming.Nature aging · 2026Article
- Skin aging: mechanisms, evaluation, and rejuvenation.The EMBO journal · 2026Review
- The metabolic intersection between immunosenescence and neuroinflammation in amyotrophic lateral sclerosis.Journal of inflammation (London, England) · 2025Review
- Membrane transporter progressive ankylosis protein homologue (Frontiers in aging · 2025Article
- Article
- NMR metabolomic modelling of age and lifespan: a multi-cohort analysis.medRxiv : the preprint server for health sciences · 2023Article
- Dyskeratosis Congenita Links Telomere Attrition to Age-Related Systemic Energetics.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Metabolic Alterations in Cellular Senescence: The Role of Citrate in Ageing and Age-Related Disease.International journal of molecular sciences · 2022Review
- Metabolic dysfunction and inflammatory disease: the role of stromal fibroblasts.The FEBS journal · 2021Review
- Radiation-Induced Senescence Reprograms Secretory and Metabolic Pathways in Colon Cancer HCT-116 Cells.International journal of molecular sciences · 2021Article
- Effects of cellular senescence on metabolic pathways in non-immune and immune cells.Mechanisms of ageing and development · 2021Review
- Danon Disease-Associated LAMP-2 Deficiency Drives Metabolic Signature Indicative of Mitochondrial Aging and Fibrosis in Cardiac Tissue and hiPSC-Derived Cardiomyocytes.Journal of clinical medicine · 2020Article
- Cellular Senescence in the Lung: The Central Role of Senescent Epithelial Cells.International journal of molecular sciences · 2020Review
- The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications.Expert review of proteomics · 2020Review
- Extracellular Citrate Fuels Cancer Cell Metabolism and Growth.Frontiers in cell and developmental biology · 2020Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Cellular senescence is often associated with irreparable DNA double strand breaks (IrrDSBs) which accumulate with chronological age (IrrDSBsen). The removal of senescent cells ameliorates several age-related diseases in mice but the translation of these findings into a clinical setting would be aided by the characterisation of non-invasive biomarkers of senescent cells. Several serum metabolites are independent indicators of chronological age and some of these accumulate outside senescent fibroblasts independently of cell cycle arrest, repairable DNA breaks and cell size (the extracellular senescence metabolome, or ESM). The post-mitotic phase of senescence is dynamic, making the detection of senescent cells in vivo difficult. An unbiased metabolomic screen of the IrrDSBsen fibroblast ESM also showed differences in the times of initiation and maintenance of different metabolites but generally the ESM altered progressively over the 20 day study period unlike the reported transcriptional profiles. This more detailed analysis of IrrDSBsen identified several new ESM metabolites that are associated with chronological ageing. Targeted analysis of citrate confirmed the dynamic nature of this metabolite in two cell lines and revealed its independence from the senescence effector p16
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