ArticleScientific reports2018
The complete methylome of an entomopathogenic bacterium reveals the existence of loci with unmethylated Adenines.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Changes in DNA methylation contribute to rapid adaptation in bacterial plant pathogen evolution.PLoS biology · 2024Article
- The Ruminant Telomere-to-Telomere (RT2T) Consortium.Nature genetics · 2024Review
- OxyR is required for oxidative stress resistance of the entomopathogenic bacteriumMicrobiology (Reading, England) · 2024Article
- AamA-mediated epigenetic control of genome-wide gene expression and phenotypic traits inMicrobial genomics · 2023Article
- Growth condition-dependent differences in methylation imply transiently differentiated DNA methylation states in Escherichia coli.G3 (Bethesda, Md.) · 2023Article
- Diverse Roles for a Conserved DNA-Methyltransferase in the Entomopathogenic BacteriumInternational journal of molecular sciences · 2022Article
- Genomic Features and Pervasive Negative Selection inMicrobiology spectrum · 2022Article
- Comparison of long-read sequencing technologies in interrogating bacteria and fly genomes.G3 (Bethesda, Md.) · 2021Article
- Convergent Rewiring of the Virulence Regulatory Network Promotes Adaptation of Ralstonia solanacearum on Resistant Tomato.Molecular biology and evolution · 2021Article
- Genome-wide methylome analysis of two strains belonging to the hypervirulent Neisseria meningitidis serogroup W ST-11 clonal complex.Scientific reports · 2021Article
- Genome-wide identification of 5-methylcytosine sites in bacterial genomes by high-throughput sequencing of MspJI restriction fragments.PloS one · 2021Article
- Conserved DNA Methyltransferases: A Window into Fundamental Mechanisms of Epigenetic Regulation in Bacteria.Trends in microbiology · 2021Review
- Novel Identification of Bacterial Epigenetic Regulations Would Benefit From a Better Exploitation of Methylomic Data.Frontiers in microbiology · 2021Review
- Bacterial genetics and molecular pathogenesis in the age of high throughput DNA sequencing.Current opinion in microbiology · 2020Review
- The bacterial epigenome.Nature reviews. Microbiology · 2020Review
- Role of the Photorhabdus Dam methyltransferase during interactions with its invertebrate hosts.PloS one · 2019Article
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Authors and funding
9 authors.
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Abstract
DNA methylation can serve to control diverse phenomena in eukaryotes and prokaryotes, including gene regulation leading to cell differentiation. In bacteria, DNA methylomes (i.e., methylation state of each base of the whole genome) have been described for several species, but methylome profile variation during the lifecycle has rarely been studied, and only in a few model organisms. Moreover, major phenotypic changes have been reported in several bacterial strains with a deregulated methyltransferase, but the corresponding methylome has rarely been described. Here we report the first methylome description of an entomopathogenic bacterium, Photorhabdus luminescens. Eight motifs displaying a high rate of methylation (>94%) were identified. The methylome was strikingly stable over course of growth, but also in a subpopulation responsible for a critical step in the bacterium's lifecycle: successful survival and proliferation in insects. The rare unmethylated GATC motifs were preferentially located in putative promoter regions, and most of them were methylated after Dam methyltransferase overexpression, suggesting that DNA methylation is involved in gene regulation. Our findings bring key insight into bacterial methylomes and encourage further research to decipher the role of loci protected from DNA methylation in gene regulation.
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