Evidence map›Paper›PMID 30108272›Full record

ArticleScientific reports2018

Dual action of the Gα

Jongyun Myeong, Juyeon Ko, Misun Kwak, Jinsung Kim, Joohan Woo, Kotdaji Ha, Chansik Hong, Dongki Yang, Hyun Jin Kim, Ju-Hong Jeon and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Cryo-EM structure of the heteromeric TRPC1/TRPC4 channel.Nature structural & molecular biology · 2025
    Article
  7. The mutual interaction of TRPC5 channel with polycystin proteins.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
    Article
  8. The odyssey of the TR(i)P journey to the cellular membrane.Frontiers in cell and developmental biology · 2024
    Review
  9. Article
  10. Article
  11. Review
  12. Negative self-regulation of transient receptor potential canonical 4 by the specific interaction with phospholipase C-δ1.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023
    Article
  13. Review
  14. The intracellular CaProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  15. Article
  16. Article
  17. Review
  18. Compartmentalization of phosphatidylinositol 4,5-bisphosphate metabolism into plasma membrane liquid-ordered/raft domains.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  19. Article
  20. Mechanisms and significance of CaCurrent opinion in physiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Jongyun MyeongDepartment of Physiology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.
Juyeon KoDepartment of Physiology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.
Misun KwakDepartment of Physiology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.
Jinsung KimDepartment of Physiology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.
Joohan WooDepartment of Physiology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.
Kotdaji HaDepartment of Physiology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.
Chansik HongDepartment of Physiology, Chosun University School of Medicine, Kwangju, 61452, Republic of Korea.ORCID 0000-0001-9684-4651
Dongki YangDepartment of Physiology, Gachon University College of Medicine, Incheon, 21936, Republic of Korea.
Hyun Jin KimDepartment of Physiology, Sungkyunkwan University School of Medicine, Suwon, 16419, Republic of Korea. kimhyunjin@skku.edu.
Ju-Hong JeonDepartment of Physiology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.
Insuk SoDepartment of Physiology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea. insuk@snu.ac.kr.
Seoul National University · KRChosun University · KRGachon University · KRSungkyunkwan University · KR

Funding

Ministry of Education (Ministry of Education of the Republic of Korea) 2015R1A6A3A0458395Ministry of Science, ICT and Future Planning (MSIP) 17-BR-01Ministry of Science, ICT and Future Planning (MSIP) 2018R1A4A1023822Seoul National University Hospital (SNUH) 03-2016-0170
6 · The paper itself

Abstract

The transient receptor potential canonical (TRPC) 1 channel is widely distributed in mammalian cells and is involved in many physiological processes. TRPC1 is primarily considered a regulatory subunit that forms heterotetrameric channels with either TRPC4 or TRPC5 subunits. Here, we suggest that the regulation of TRPC1/4 and TRPC1/5 heterotetrameric channels by the Gα

Indexed as

GTP-Binding Protein alpha Subunits, Gq-G11HEK293 CellsHumansPatch-Clamp TechniquesPhosphatidylinositol 4,5-DiphosphatePhospholipase C betaProtein MultimerizationSignal TransductionTRPC Cation ChannelsGTP-Binding Protein alpha Subunits, Gq-G11Phosphatidylinositol 4,5-DiphosphatePhospholipase C betatransient receptor potential cation channel, subfamily C, member 1TRPC4 ion channelTRPC5 protein, humanTRPC Cation Channels

Identifiers

PMID30108272
PMCPMC6092394
OpenAlexW2885476833

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.