ArticleScientific reports2018
Quantitative analysis of retinal and choroidal microvascular changes in patients with diabetes.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Choroidal vascularity index is independent of ocular and image-based factors in healthy eyes: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Optical coherence tomography evaluation of choroidal structure changes in diabetic retinopathy patients: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- Baseline Nonperfusion and Deep Capillary Plexus Ischemia Predict Two-Year Retinal Nonperfusion Progression in Diabetic Retinopathy.Investigative ophthalmology & visual science · 2026Observational
- Automated FAZ segmentation and diabetic retinopathy classification using OCTA images.BMC ophthalmology · 2025Article
- Retinal vessel tortuosity and fractal dimension in diabetic retinopathy.International journal of retina and vitreous · 2025Article
- Diagnostic value of choroidal vascular density in predicting the progression of diabetic retinopathy.Scientific reports · 2025Article
- Assessing Preclinical Diabetic Retinopathy: The Role of Optical Coherence Tomography Angiography.Cureus · 2024Article
- Widefield swept-source optical coherence tomography angiography metrics associated with neovascular glaucoma in patients with proliferative diabetic retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Choroidal Changes in Patients with Diabetic Retinopathy: A Retrospective Study.Diagnostics (Basel, Switzerland) · 2024Article
- Insights into the pattern of choroidal vascularity index changes in idiopathic macular hole.Scientific reports · 2024Article
- Retinal and Choroidal Vascularization Parameters in Patients with Type 2 Diabetes Without Diabetic Retinopathy.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- The Royal College of Ophthalmologists' National Ophthalmology Database Study of Cataract Surgery: Report 12, Risk factors for suprachoroidal haemorrhage during cataract surgery.Eye (London, England) · 2023Article
- Acute hyperglycemia compromises the responses of choroidal vessels using swept-source optical coherence tomography during dark and light adaptations.Frontiers in endocrinology · 2023Article
- Methods to evaluate vascular function: a crucial approach towards predictive, preventive, and personalised medicine.The EPMA journal · 2022Review
- Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus-Report 2: Diabetic Kidney Disease.Journal of clinical medicine · 2021Article
- Early neurovascular retinal changes detected by swept-source OCT in type 2 diabetes and association with diabetic kidney disease.International journal of retina and vitreous · 2021Article
- Assessment of the retinal vasculature in healthy Chinese preschool children aged 4-6 years old using optical coherence tomography angiography.BMC ophthalmology · 2021Article
- Choroidal vascularity index in pseudoexfoliative glaucoma.International ophthalmology · 2021Article
- Analysis of the Choroid and Its Relationship with the Outer Retina in Patients with Diabetes Mellitus Using Binarization Techniques Based on Spectral-Domain Optical Coherence Tomography.Journal of clinical medicine · 2021Article
- Foveal Avascular Zone Does Not Correspond to Choroidal Characteristics in Patients with Diabetic Retinopathy: A Single-Center Cross-Sectional Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The relationship between choroidal and retinal microvascular changes has not yet been well described, and there were limited data on diagnostic ability of optical coherence tomography (OCT)-derived vascular parameters for determining diabetic retinopathy (DR) progression. We quantitatively analyzed OCT-derived vascular parameters at superficial (SCP) and deep retinal capillary plexus (DCP), and choroid. We assessed foveal avascular zone (FAZ), vessel density, vessel length density, and choroidal vascularity index in conjunction with DR stage. In this study, patients with diabetes and healthy controls were retrospectively analyzed. One-hundred seventy-four eyes were divided into six groups as follows: Healthy controls, no DR, mild non-proliferative DR (NPDR), moderate NPDR, severe NPDR, and proliferative DR. There were significant quantitative changes in retinal and choroidal vascular parameters with DR progression. The FAZ area and perimeter correlated positively with worsening DR severity; the FAZ circularity index, retinal vessel density, retinal vessel length density, and choroidal vascularity index correlated negatively with worsening severity. Among these, FAZ circulatory index demonstrated good diagnostic performance for DR. Our results cautiously suggest that functional circulatory disturbances in retinal and choroidal vasculatures occur before DR presents. As DR progresses, DCP retinal microvasculature changes precede SCP changes.
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Registered trials
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