ArticleScientific reports2018
Understanding the Mechanism of Action of the Anti-Dandruff Agent Zinc Pyrithione against Malassezia restricta.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06307223 (Efficacy and Safety of 30% Supramolecular Salicylic Acid Combined With Supramolecular Active Zinc in the Treatment of Malassezia Folliculitis), which is not on this map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety of 30% Supramolecular Salicylic Acid Combined With Supramolecular Active Zinc in the Treatment of Malassezia Folliculitis
Who cites it
31 citing papers in PubMed, 65 citations in OpenAlex.
- Understanding the dandruff flare-up: A cascade of measurable and perceptible changes to scalp health.International journal of cosmetic science · 2025Trial
- Natural Product-Inspired Antifungal Drugs Introduced for Human Use from 1872 to August 2026.Antibiotics (Basel, Switzerland) · 2026Review
- Managing Malassezia species and related infections: new insights into recent natural and synthetic antifungal compounds and their mechanism of action.Molecular diversity · 2026Review
- Cytometric proteome profiling of GFP-tagged yeast for characterizing novel antifungals.Communications biology · 2026Article
- Redox-Controlled Chalcogen Bonding as a Modulator of ZnClJournal of the American Chemical Society · 2026Article
- Iron acquisition mechanisms of human skin-associated fungi.FEMS yeast research · 2026Review
- Zinc pyrithione impairs iron-sulfur cluster biogenesis in Mycobacterium tuberculosis.BMC microbiology · 2025Article
- A novel enzymatic approach for a targeted fungal growth inhibition.BMC microbiology · 2025Article
- Article
- Diagnostic challenges and treatment breakthroughs inFrontiers in cellular and infection microbiology · 2025Article
- Article
- More yeast, more problems?: reevaluating the role of Malassezia in seborrheic dermatitis.Archives of dermatological research · 2024Review
- Article
- Malassezia restricta-mediated Lipoperoxidation: A Novel Trigger in Dandruff.Acta dermato-venereologica · 2023Article
- The human pathobiontProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Zinc pyrithione is a potent inhibitor of PLJournal of enzyme inhibition and medicinal chemistry · 2022Article
- A Novel Approach To Identify Inhibitors of Iron Acquisition Systems of Pseudomonas aeruginosa.Microbiology spectrum · 2022Article
- Rational Design of Silicon-Based Zinc Ionophores.Angewandte Chemie (International ed. in English) · 2022Article
- Investigating Structural Property Relationships to Enable Repurposing of Pharmaceuticals as Zinc Ionophores.Pharmaceutics · 2021Article
- Targeted Delivery of Zinc Pyrithione to Skin Epithelia.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dandruff is known to be associated with Malassezia restricta. Zinc pyrithione (ZPT) has been used as an ingredient in anti-dandruff treatments. The mechanism of ZPT has been investigated in several studies; however, a non-pathogenic model yeast, such as Saccharomyces cerevisiae was most often used. The aim of the present study was to understand how ZPT inhibits the growth of M. restricta. We analyzed the cellular metal content and transcriptome profile of ZPT-treated M. restricta cells and found that ZPT treatment dramatically increased cellular zinc levels, along with a small increase in cellular copper levels. Moreover, our transcriptome analysis showed that ZPT inhibits Fe-S cluster synthesis in M. restricta. We also observed that ZPT treatment significantly reduced the expression of lipases, whose activities contribute to the survival and virulence of M. restricta on human skin. Therefore, the results of our study suggest that at least three inhibitory mechanisms are associated with the action of ZPT against M. restricta: (i) an increase in cellular zinc levels, (ii) inhibition of mitochondrial function, and (iii) a decrease in lipase expression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.