Evidence map›Paper›PMID 30108224›Full record

ReviewNPJ primary care respiratory medicine2018

Exercise-induced bronchoconstriction: prevalence, pathophysiology, patient impact, diagnosis and management.

Bhumika Aggarwal, Aruni Mulgirigama, Norbert Berend

Abstract readReview
In one paragraph

Review in NPJ primary care respiratory medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Exploring the role of cold air in airway hyperresponsiveness and asthma diagnostic testing: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  2. Pooled it
  3. Guideline
  4. Pooled it
  5. Pulmonary rehabilitation versus usual care for adults with asthma.The Cochrane database of systematic reviews · 2022
    Pooled it
  6. Sex Differences in Exercise-Induced Bronchoconstriction in Athletes: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020
    Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Article
  11. Mechanisms and therapeutic strategies of asthma: from bench to bedside.Signal transduction and targeted therapy · 2026
    Review
  12. Article
  13. Article
  14. Exercise and large airway issues.Physiological reports · 2025
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bhumika AggarwalRespiratory, Global Classic & Established Products, GSK, Singapore, Singapore. bhumika.x.aggarwal@gsk.com.
Aruni MulgirigamaRespiratory, Global Classic & Established Products, GSK, Middlesex, London, UK.
Norbert BerendGlobal Respiratory Franchise, GSK, Middlesex, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exercise-induced bronchoconstriction (EIB) can occur in individuals with and without asthma, and is prevalent among athletes of all levels. In patients with asthma, symptoms of EIB significantly increase the proportion reporting feelings of fearfulness, frustration, isolation, depression and embarrassment compared with those without symptoms. EIB can also prevent patients with asthma from participating in exercise and negatively impact their quality of life. Diagnosis of EIB is based on symptoms and spirometry or bronchial provocation tests; owing to low awareness of EIB and lack of simple, standardised diagnostic methods, under-diagnosis and mis-diagnosis of EIB are common. To improve the rates of diagnosis of EIB in primary care, validated and widely accepted symptom-based questionnaires are needed that can accurately replicate the current diagnostic standards (forced expiratory volume in 1 s reductions observed following exercise or bronchoprovocation challenge) in patients with and without asthma. In patients without asthma, EIB can be managed by various non-pharmacological methods and the use of pre-exercise short-acting β

Indexed as

ExerciseAdolescentAsthmaBronchial DiseasesChildConstriction, PathologicFemaleHumansMale

Identifiers

PMID30108224
PMCPMC6092370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.