Evidence map›Paper›PMID 30108203›Full record

ArticleTranslational psychiatry2018

Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders.

Gauri Ang, Laura E McKillop, Ross Purple, Cristina Blanco-Duque, Stuart N Peirson, Russell G Foster, Paul J Harrison, Rolf Sprengel, Kay E Davies, Peter L Oliver and 2 more

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
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  3. CB-1 receptor agonist drastically changes oscillatory activity, defining active sleep.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Gauri AngDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.
Laura E McKillopDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.
Ross PurpleDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.
Cristina Blanco-DuqueDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.ORCID http://orcid.org/0000-0003-0212-2880
Stuart N PeirsonSleep and Circadian Neuroscience Institute, Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK.
Russell G FosterSleep and Circadian Neuroscience Institute, Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK.ORCID http://orcid.org/0000-0001-6055-2067
Paul J HarrisonDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.ORCID http://orcid.org/0000-0002-6719-1126
Rolf SprengelResearch Group of the Max Planck Institute for Medical Research at the Inst. for Anatomy and Cell Biology of the University Heidelberg, INF 307, D-69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-3370-0970
Kay E DaviesDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.
Peter L OliverDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.
David M BannermanDepartment of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK.
Vladyslav V VyazovskiyDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK. vladyslav.vyazovskiy@dpag.ox.ac.uk.
University of Oxford · GBHeidelberg University · DEOxford Health NHS Foundation Trust · GB

Funding

Biotechnology and Biological Sciences Research Council BB/K011847/1Medical Research Council MC_EX_MR/P502005/1Medical Research Council MC_UU_12021/2Medical Research Council MR/L003635/1Wellcome TrustWellcome Trust 098461/Z/12/Z
6 · The paper itself

Abstract

Sleep EEG spindles have been implicated in attention, sensory processing, synaptic plasticity and memory consolidation. In humans, deficits in sleep spindles have been reported in a wide range of neurological and psychiatric disorders, including schizophrenia. Genome-wide association studies have suggested a link between schizophrenia and genes associated with synaptic plasticity, including the Gria1 gene which codes for the GluA1 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. Gria1

Indexed as

AnimalsDisease Models, AnimalElectroencephalographyGenome-Wide Association StudyHumansMaleMemory ConsolidationMiceMice, KnockoutNeuronal PlasticityPhenotypePsychomotor AgitationReceptors, AMPASchizophreniaSleepSleep DeprivationReceptors, AMPA

Identifiers

PMID30108203
PMCPMC6092338
OpenAlexW2887528073

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.