Evidence map›Paper›PMID 30108168›Full record

ArticlemBio2018

Nitric Oxide Disrupts Zinc Homeostasis in Salmonella enterica Serovar Typhimurium.

Elaine R Frawley, Joyce E Karlinsey, Anshika Singhal, Stephen J Libby, Paschalis-Thomas Doulias, Harry Ischiropoulos, Ferric C Fang

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Metal Nanoparticles in Infection and Immunity.Immunological investigations · 2020
    Pooled it
  2. Review
  3. bioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Manganese Utilization inFrontiers in cell and developmental biology · 2022
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Microorganisms · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Elaine R FrawleyDepartment of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Joyce E Karlinsey *Department of Microbiology, University of Washington, Seattle, Washington, USA.
Anshika Singhal *Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Stephen J LibbyDepartment of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Paschalis-Thomas DouliasDepartment of Pediatrics, The Children's Hospital of Philadelphia Research Institute and The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Harry IschiropoulosDepartment of Pediatrics, The Children's Hospital of Philadelphia Research Institute and The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ferric C FangDepartment of Laboratory Medicine, University of Washington, Seattle, Washington, USA fcfang@uw.edu.ORCID 0000-0002-3243-110X
University of Washington · USChildren's Hospital of Philadelphia · US

Funding

Reactive Species in Vascular Disease: Mechanisms of InjuryR01HL054926 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ISCHIROPOULOS, HARRY · 1997 to 2023
$7.7M
Typhoid Pathogenesis and ImmunityR01AI112640 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2015 to 2019
$2.1M
Antimicrobial Actions of Nitric OxideR01AI118962 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2016 to 2020
$1.9M
Citrate and Metal Efflux by IceTF32AI112101 · NIAID · UNIVERSITY OF WASHINGTON · PI FRAWLEY, ELAINE R. · 2014 to 2016
$135k
NHLBI NIH HHS R01 HL054926NIAID NIH HHS F32 AI112101NIAID NIH HHS R01 AI112640NIAID NIH HHS R01 AI118962
6 · The paper itself

Abstract

Nitric oxide (NO·) produced by mammalian cells exerts antimicrobial actions that result primarily from the modification of protein thiols (

Indexed as

AnimalsAnti-Bacterial AgentsHomeostasisMacrophagesMiceMicrobial ViabilityNitric OxideRAW 264.7 CellsSalmonella Infections, AnimalSalmonella typhimuriumZincAnti-Bacterial AgentsNitric OxideZincnitric oxidepathogenesisSalmonellatransporterszinc homeostasis

Identifiers

PMID30108168
PMCPMC6094482
OpenAlexW2885195947

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.