Evidence map›Paper›PMID 30108161›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2018

Tamoxifen Directly Interacts with the Dopamine Transporter.

Sarah R Mikelman, Bipasha Guptaroy, Kyle C Schmitt, Kymry T Jones, Juan Zhen, Maarten E A Reith, Margaret E Gnegy

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Sex-dependent effects of tamoxifen on mouse behavior.Behavioral and brain functions : BBF · 2025
    Article
  2. Review
  3. Article
  4. Review
  5. Water Extract ofFrontiers in endocrinology · 2022
    Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sarah R MikelmanGnegy Laboratory, Department of Pharmacology, University of Michigan School of Medicine, Ann Arbor, Michigan (S.R.M., B.G., M.E.G.); and Reith Laboratory, Department of Psychiatry, University of New York School of Medicine, New York, New York (K.C.S., K.T.J., J.Z., M.E.A.R.).
Bipasha GuptaroyGnegy Laboratory, Department of Pharmacology, University of Michigan School of Medicine, Ann Arbor, Michigan (S.R.M., B.G., M.E.G.); and Reith Laboratory, Department of Psychiatry, University of New York School of Medicine, New York, New York (K.C.S., K.T.J., J.Z., M.E.A.R.).
Kyle C SchmittGnegy Laboratory, Department of Pharmacology, University of Michigan School of Medicine, Ann Arbor, Michigan (S.R.M., B.G., M.E.G.); and Reith Laboratory, Department of Psychiatry, University of New York School of Medicine, New York, New York (K.C.S., K.T.J., J.Z., M.E.A.R.).
Kymry T JonesGnegy Laboratory, Department of Pharmacology, University of Michigan School of Medicine, Ann Arbor, Michigan (S.R.M., B.G., M.E.G.); and Reith Laboratory, Department of Psychiatry, University of New York School of Medicine, New York, New York (K.C.S., K.T.J., J.Z., M.E.A.R.).
Juan ZhenGnegy Laboratory, Department of Pharmacology, University of Michigan School of Medicine, Ann Arbor, Michigan (S.R.M., B.G., M.E.G.); and Reith Laboratory, Department of Psychiatry, University of New York School of Medicine, New York, New York (K.C.S., K.T.J., J.Z., M.E.A.R.).
Maarten E A ReithGnegy Laboratory, Department of Pharmacology, University of Michigan School of Medicine, Ann Arbor, Michigan (S.R.M., B.G., M.E.G.); and Reith Laboratory, Department of Psychiatry, University of New York School of Medicine, New York, New York (K.C.S., K.T.J., J.Z., M.E.A.R.).
Margaret E GnegyGnegy Laboratory, Department of Pharmacology, University of Michigan School of Medicine, Ann Arbor, Michigan (S.R.M., B.G., M.E.G.); and Reith Laboratory, Department of Psychiatry, University of New York School of Medicine, New York, New York (K.C.S., K.T.J., J.Z., M.E.A.R.) pgnegy@umich.edu.
University of Michigan–Ann Arbor · USNew York University · US

Funding

INTERDEPARTMENTAL TRAINING IN PHARMACOLOGICAL SCIENCEST32GM007767 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 1985 to 2019
$10.2M
PHARMACOLOGY OF DOPAMINE RELEASE BY AMPHETAMINER01DA011697 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GNEGY, MARGARET E · 2000 to 2016
$5.3M
SUBSTANCE ABUSE INTERDISCIPLINARY TRAINING PROGRAMT32DA007267 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GNEGY, MARGARET E · 1994 to 2015
$4.5M
Dopamine Transporters: Mechanisms of Ligand InteractionR01DA019676 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI REITH, MAARTEN E · 2006 to 2016
$2.9M
NIDA NIH HHS R01 DA011697NIDA NIH HHS R01 DA019676NIDA NIH HHS T32 DA007267NIGMS NIH HHS T32 GM007767
6 · The paper itself

Abstract

The selective estrogen receptor modulator tamoxifen increases extracellular dopamine in vivo and acts as a neuroprotectant in models of dopamine neurotoxicity. We investigated the effect of tamoxifen on dopamine transporter (DAT)-mediated dopamine uptake, dopamine efflux, and [

Indexed as

AmphetamineAnimalsBinding SitesCell LineCentral Nervous System StimulantsCocaineCorpus StriatumDopamineDopamine Plasma Membrane Transport ProteinsDopamine Uptake InhibitorsMaleRatsSwineSynaptosomesTamoxifen(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl esterAmphetamineCentral Nervous System StimulantsCocaineDopamineDopamine Plasma Membrane Transport ProteinsDopamine Uptake InhibitorsTamoxifen

Identifiers

PMID30108161
PMCPMC7250473
OpenAlexW2885678148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.