ArticleJournal of lipid research2018
Genome-wide association study identifies novel recessive genetic variants for high TGs in an Arab population.
Article in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Functional ADAM12 variants modulate proteolytic activity and influence metabolic traits.Scientific reports · 2026Article
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- Association of mitochondrial haplogroup H with reduced risk of type 2 Diabetes among Gulf Region Arabs.Frontiers in endocrinology · 2024Article
- Evaluation of the correlation between fetuin-B levels and essential hypertension: a cross-sectional study.Endocrine connections · 2023Article
- The miR-668 binding site variant rs1046322 onFrontiers in endocrinology · 2023Article
- Single nucleotide polymorphisms in vitamin D binding protein and 25-hydroxylase genes affect vitamin D levels in adolescents of Arab ethnicity in Kuwait.Frontiers in endocrinology · 2023Article
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- Unraveling a fine-scale high genetic heterogeneity and recent continental connections of an Arabian Peninsula population.European journal of human genetics : EJHG · 2022Article
- A Nutrigenetic Update on CETP Gene-Diet Interactions on Lipid-Related Outcomes.Current atherosclerosis reports · 2022Review
- Comprehensive Statistical and Bioinformatics Analysis in the Deciphering of Putative Mechanisms by Which Lipid-Associated GWAS Loci Contribute to Coronary Artery Disease.Biomedicines · 2022Article
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- Multi-scale inference of genetic trait architecture using biologically annotated neural networks.PLoS genetics · 2021Article
- Application of a novel haplotype-based scan for local adaptation to study high-altitude adaptation in rhesus macaques.Evolution letters · 2021Article
- Genome-wide landscape establishes novel association signals for metabolic traits in the Arab population.Human genetics · 2021Article
- Identification of Recessively Inherited Genetic Variants Potentially Linked to Pancreatic Cancer Risk.Frontiers in oncology · 2021Article
- Serum Fetuin-B Levels Are Elevated in Women with Metabolic Syndrome and Associated with Increased Oxidative Stress.Oxidative medicine and cellular longevity · 2021Article
- Genome-Wide Selection Scan in an Arabian Peninsula Population Identifies a TNKS Haplotype Linked to Metabolic Traits and Hypertension.Genome biology and evolution · 2020Article
- Genome-wide association study identifies novel risk variants from RPS6KA1, CADPS, VARS, and DHX58 for fasting plasma glucose in Arab population.Scientific reports · 2020Article
- A Perception on Genome-Wide Genetic Analysis of Metabolic Traits in Arab Populations.Frontiers in endocrinology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal blood lipid levels are influenced by genetic and lifestyle/dietary factors. Although many genetic variants associated with blood lipid traits have been identified in Europeans, similar data in Middle Eastern populations are limited. We performed a genome-wide association study with Arab individuals (discovery cohort: 1,353; replication cohort: 1,176) from Kuwait to identify possible associations of genetic variants with high lipid levels. We used Illumina HumanOmniExpress BeadChip and candidate SNP genotyping in the discovery and replication phases, respectively. For association tests, we used genetic models that were based on additive and recessive modes of inheritance. High triglycerides (TGs) were recessively associated with six risk variants (rs1002487/
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