Evidence map›Paper›PMID 30108148›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Structure of the mammalian TRPM7, a magnesium channel required during embryonic development.

Jingjing Duan, Zongli Li, Jian Li, Raymond E Hulse, Ana Santa-Cruz, William C Valinsky, Sunday A Abiria, Grigory Krapivinsky, Jin Zhang, David E Clapham

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 126 citations in OpenAlex.

  1. Article
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  11. Unlocking TRPM7 interactions: A database-driven quest.Computational and structural biotechnology journal · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Navigating the Controversies: Role of TRPM Channels in Pain States.International journal of molecular sciences · 2024
    Review
  18. Article
  19. Article
  20. TRPM channels in health and disease.Nature reviews. Nephrology · 2024
    Review

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Jingjing DuanDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115.
Zongli LiHoward Hughes Medical Institute, Harvard Medical School, Boston, MA 02115.
Jian LiSchool of Basic Medical Sciences, Nanchang University, Nanchang, 330031 Jiangxi, China.
Raymond E HulseDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115.
Ana Santa-CruzDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115.
William C ValinskyJanelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147.ORCID 0000-0001-7736-9146
Sunday A AbiriaDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115.
Grigory KrapivinskyDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115.
Jin ZhangDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115; zhangxiaokong@hotmail.com claphamd@hhmi.org.
David E ClaphamDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115; zhangxiaokong@hotmail.com claphamd@hhmi.org.ORCID 0000-0002-4459-9428
Boston Children's Hospital · USHoward Hughes Medical Institute · USNanchang University · CN

Funding

RESEARCH METHODS IN PEDIATRICS HEART DISEASET32HL007572 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI Sarah D DE FERRANTI, Jane W. Newburger · 1985 to 2026
$13.0M
Howard Hughes Medical InstituteNHLBI NIH HHS T32 HL007572
6 · The paper itself

Abstract

The transient receptor potential ion channel subfamily M, member 7 (TRPM7), is a ubiquitously expressed protein that is required for mouse embryonic development. TRPM7 contains both an ion channel and an α-kinase. The channel domain comprises a nonselective cation channel with notable permeability to Mg

Indexed as

Embryo, MammalianEmbryonic DevelopmentEvolution, MolecularAnimalsMiceProtein DomainsTRPM Cation ChannelsTrpm7 protein, mouseTRPM Cation Channelschanzymeion channelkinaseTRP channelzinc

Identifiers

PMID30108148
PMCPMC6126765
OpenAlexW2885142817

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.