Evidence map›Paper›PMID 30108145›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Crystal Structure of a ligand-bound LacY-Nanobody Complex.

Hemant Kumar, Janet S Finer-Moore, Xiaoxu Jiang, Irina Smirnova, Vladimir Kasho, Els Pardon, Jan Steyaert, H Ronald Kaback, Robert M Stroud

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Deciphering the crystal structure of a novel nanobody against the NEIL1 DNA glycosylase.Acta crystallographica. Section D, Structural biology · 2024
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Function Trumps Form in Two Sugar Symporters,International journal of molecular sciences · 2021
    Review
  13. Review
  14. Review
  15. Exploring cellular biochemistry with nanobodies.The Journal of biological chemistry · 2020
    Review
  16. Plant glucose transporter structure and function.Pflugers Archiv : European journal of physiology · 2020
    Review
  17. Isolation and structural characterization of a ZnThe Journal of biological chemistry · 2020
    Article
  18. Article
  19. It takes two to tango: The dance of the permease.The Journal of general physiology · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Hemant KumarDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA 94158.
Janet S Finer-MooreDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA 94158.
Xiaoxu JiangDepartment of Physiology, University of California, Los Angeles, CA 90095.
Irina SmirnovaDepartment of Physiology, University of California, Los Angeles, CA 90095.
Vladimir KashoDepartment of Physiology, University of California, Los Angeles, CA 90095.
Els PardonVIB-VUB Center for Structural Biology, VIB, 1050 Brussels, Belgium.ORCID 0000-0002-2466-0172
Jan SteyaertVIB-VUB Center for Structural Biology, VIB, 1050 Brussels, Belgium.
H Ronald KabackDepartment of Physiology, University of California, Los Angeles, CA 90095; rkaback@mednet.ucla.edu stroud@msg.ucsf.edu.
Robert M StroudDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA 94158; rkaback@mednet.ucla.edu stroud@msg.ucsf.edu.
University of California, Los Angeles · USUniversity of California, San Francisco · USVrije Universiteit Brussel · BE

Funding

STRUCTURE/FUNCTION OF PROTEINS AT MOLECULAR LEVELR01GM024485 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STROUD, ROBERT M · 1985 to 2024
$7.5M
Dynamics of the Lactose Permease of Escherichia ColiR01GM120043 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WRIGHT, ERNEST M · 2016 to 2019
$1.8M
NIGMS NIH HHS R01 GM024485NIGMS NIH HHS R01 GM120043
6 · The paper itself

Abstract

The lactose permease of

Indexed as

Crystallography, X-RayEscherichia coliEscherichia coli ProteinsMonosaccharide Transport ProteinsMutationProtein Structure, QuaternarySingle-Domain AntibodiesSymportersEscherichia coli ProteinsLacY protein, E coliMonosaccharide Transport ProteinsSingle-Domain AntibodiesSymportersconformational changeMajor Facilitator Superfamilymembrane proteintransportX-ray structure

Identifiers

PMID30108145
PMCPMC6126719
OpenAlexW2887979370

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.