Evidence map›Paper›PMID 30107910›Full record

ArticleBiochemical and biophysical research communications2018

Ubiquinol promotes retinal ganglion cell survival and blocks the apoptotic pathway in ischemic retinal degeneration.

Won-Kyu Ju, Myoung Sup Shim, Keun-Young Kim, Jung Hyun Bu, Tae Lim Park, Sangphil Ahn, Robert N Weinreb

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
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  6. Protein misfolding and mitochondrial dysfunction in glaucoma.Frontiers in cell and developmental biology · 2025
    Review
  7. Article
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  9. Article
  10. Article
  11. Review
  12. Review
  13. The Role of Citicoline and Coenzyme Q10 in Retinal Pathology.International journal of molecular sciences · 2023
    Review
  14. Posttranslational modifications of proteins in diseased retina.Frontiers in cellular neuroscience · 2023
    Review
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Won-Kyu JuHamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA. Electronic address: wju@ucsd.edu.
Myoung Sup ShimHamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA.
Keun-Young KimNational Center for Microscopy and Imaging Research, Department of Neuroscience, University of California San Diego, La Jolla, CA, USA.
Jung Hyun BuHamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA.
Tae Lim ParkHamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA.
Sangphil AhnHamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA.
Robert N WeinrebHamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA.
University of California, San Diego · US

Funding

IVEM and Image Analysis ResourceP41GM103412 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2012 to 2019
$17.9M
Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Derek Stuart Welsbie · 2012 to 2026
$10.3M
Mitochondrial Dysfunction in Glaucomatous Optic NeuropathyR01EY018658 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JU, WONKYU · 2009 to 2017
$3.5M
NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY018658NIGMS NIH HHS P41 GM103412
6 · The paper itself

Abstract

Coenzyme Q10 (CoQ

Indexed as

AnimalsAntioxidantsApoptosisAstrocytesbcl-2-Associated X Proteinbcl-Associated Death Proteinbcl-X ProteinCaspase 3Cell SurvivalDisease Models, AnimalFemaleGene Expression RegulationIntraocular PressureMiceMice, Inbred C57BLMicrogliaAntioxidantsBad protein, mouseBax protein, mousebcl-2-Associated X ProteinBcl2l1 protein, mousebcl-Associated Death Proteinbcl-X ProteinCasp3 protein, mouseCaspase 3Reactive Oxygen SpeciesubiquinolUbiquinoneApoptosisIschemiaRetinaRetinal ganglion cellUbiquinol

Identifiers

PMID30107910
PMCPMC6133725
OpenAlexW2885740766

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.