Evidence map›Paper›PMID 30107492›Full record

ArticleAmerican journal of hypertension2018

Measurement of Central Aortic Blood Pressure in Youth: Role of Obesity and Sex.

Michelle M Harbin, Neil E Hultgren, Aaron S Kelly, Donald R Dengel, Nicholas G Evanoff, Justin R Ryder

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of hypertension, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Michelle M HarbinLaboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA.
Neil E HultgrenLaboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA.
Aaron S KellyDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Donald R DengelLaboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA.
Nicholas G EvanoffLaboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA.
Justin R RyderDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

Funding

Validation of Circulating Endothelial Cells and Microparticles in YouthR01HL110957 · NHLBI · UNIVERSITY OF MINNESOTA · PI KELLY, AARON S · 2012 to 2016
$3.2M
NHLBI NIH HHS R01 HL110957
6 · The paper itself

Abstract

backgroundThe relationship between pediatric severe obesity (SO) and central aortic blood pressure (BP) has yet to be established.

methodsWe conducted a cross-sectional study of 348 youth (48.5% male, age 12.7 ± 0.1 years) with a wide range of body mass index (BMI) values: normal weight (NW; ≥5th and <85th BMI percentiles), overweight/obesity (OW/OB; 85th to <120% of the 95th BMI percentile), and SO (≥120% of the 95th BMI percentile). Measures of central aortic BP were obtained via applanation tonometry with SphygmoCor MM3 software.

resultsAfter adjustment for covariates, no significant sex differences were observed for radial-aortic systolic blood pressure (SBP) (P = 0.39), carotid-aortic SBP (P = 0.99), radial-aortic diastolic blood pressure (DBP) (P = 0.44), and carotid-aortic DBP (P = 0.53). Compared to youth with NW, youth with SO exhibited higher radial-aortic SBP (SO vs. NW: 102 ± 1 mm Hg vs. 90 ± 1 mm Hg, P<0.001), carotid-aortic SBP (SO vs. NW: 121 ± 1 mm Hg vs. 109 ± 1 mm Hg, P<0.001), and carotid-aortic DBP (SO vs. NW: 60 ± 1 mm Hg vs. 56 ± 1 mm Hg, P = 0.04). Compared to youth with OW/OB, youth with SO had higher radial-aortic SBP (OW/OB: 97 ± 1 mm Hg, P = 0.002) and carotid-aortic SBP (OW/OB: 114 ± 1 mm Hg, P = 0.007). After adjusting for either total-body percent fat mass or visceral adipose tissue, BMI was still a significant predictor of both radial-aortic and carotid-aortic SBP and DBP (P<0.001, all).

conclusionsIn a cohort of youth with a wide range of adiposity levels, central aortic BP was elevated among individuals with SO and associated with BMI but not body fatness.

Indexed as

AdiposityArterial PressureAdolescentAge FactorsBlood Pressure DeterminationBody Mass IndexChildCross-Sectional StudiesFemaleHumansHypertensionMaleManometryMinnesotaPediatric ObesityPredictive Value of Tests

Identifiers

PMID30107492
PMCPMC6233689

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.