Evidence map›Paper›PMID 30107294›Full record

ArticleRedox biology2018

Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls.

Erika Koltai, Zoltan Bori, Peter Osvath, Ferenc Ihasz, Szablics Peter, Geza Toth, Hans Degens, Jörn Rittweger, Istvan Boldogh, Zsolt Radak

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Non-coding RNAs in exercise immunology: A systematic review.Journal of sport and health science · 2024
    Pooled it
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  9. Exosomes and microRNAs as mediators of the exercise.European journal of medical research · 2025
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  15. NADMolecular and cellular biochemistry · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 5 countries.

Erika KoltaiResearch Institute of Sport Science, University of Physical Education, Budapest, Hungary.
Zoltan BoriResearch Institute of Sport Science, University of Physical Education, Budapest, Hungary.
Peter OsvathDepartment of Health Sciences and Sports Medicine, University of Physical Education, Budapest, Hungary.
Ferenc IhaszHungary Institute of Sport Science, Faculty of Education and Psychology, Eotvos University, Szombathely, Hungary.
Szablics PeterInstitute of Physical Education and Sport Science, JGYPK, University of Szeged, Szeged, Hungary.
Geza TothAffidea Diagnostic Center, Budapest, Hungary.
Hans DegensSchool of Healthcare Science, Manchester Metropolitan University, UK; Institute of Sport Science and Innovations, Lithuanian Sports University, Lithuania.
Jörn RittwegerDivision Space Physiology, Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany.
Istvan BoldoghUniversity of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Zsolt RadakResearch Institute of Sport Science, University of Physical Education, Budapest, Hungary. Electronic address: radak@tf.hu.
Hungarian University of Sports Science · HUDeutsches Zentrum für Luft- und Raumfahrt e. V. (DLR) · DEEötvös Loránd University · HUManchester Metropolitan University · GBThe University of Texas Medical Branch at Galveston · USUniversity of Szeged · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regular physical exercise has health benefits and can prevent some of the ageing-associated muscle deteriorations. However, the biochemical mechanisms underlying this exercise benefit, especially in human tissues, are not well known. To investigate, we assessed this using miRNA profiling, mRNA and protein levels of anti-oxidant and metabolic proteins in the vastus lateralis muscle of master athletes aged over 65 years and age-matched controls. Master athletes had lower levels of miR-7, while mRNA or protein levels of SIRT3, SIRT1, SOD2, and FOXO1 levels were significantly higher in the vastus lateralis muscle of master athletes compared to muscles of age-matched controls. These results suggest that regular exercise results in better cellular metabolism and antioxidant capacity via maintaining physiological state of mitochondria and efficient ATP production and decreasing ageing-related inflammation as indicated by the lower level of miR-7 in master athletes.

Indexed as

ExerciseUp-RegulationAgedAgingAthletesDown-RegulationFemaleGene ExpressionHumansMaleMicroRNAsMiddle AgedMuscle, SkeletalRNA, MessengerSedentary BehaviorSirtuin 3MicroRNAsMIRN7-1 microRNA, humanRNA, MessengerSIRT3 protein, humanSirtuin 3Superoxide DismutaseSuperoxide Dismutase 2Anti-oxidantMaster athletemiRNASkeletal muscle

Identifiers

PMID30107294
PMCPMC6092475
OpenAlexW2887132551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.