Evidence map›Paper›PMID 30107292›Full record

ArticleEnvironment international2018

A multicity study of air pollution and cardiorespiratory emergency department visits: Comparing approaches for combining estimates across cities.

Jenna R Krall, Howard H Chang, Lance A Waller, James A Mulholland, Andrea Winquist, Evelyn O Talbott, Judith R Rager, Paige E Tolbert, Stefanie Ebelt Sarnat

Abstract read
In one paragraph

Article in Environment international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Observational
  6. Review
  7. Article
  8. Article
  9. Assessing the health estimation capacity of air pollution exposure prediction models.Environmental health : a global access science source · 2022
    Article
  10. Impacts of Environmental Insults on Cardiovascular Aging.Current environmental health reports · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Data Science in Environmental Health Research.Current epidemiology reports · 2019
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jenna R KrallDepartment of Global and Community Health, George Mason University, 4400 University Drive, MS 5B7, Fairfax, VA 22030, United States. Electronic address: jkrall@gmu.edu.
Howard H ChangDepartment of Biostatistics & Bioinformatics, Emory University, 1518 Clifton Rd. NE, Atlanta, GA 30322, United States. Electronic address: howard.chang@emory.edu.
Lance A WallerDepartment of Biostatistics & Bioinformatics, Emory University, 1518 Clifton Rd. NE, Atlanta, GA 30322, United States. Electronic address: lwaller@emory.edu.
James A MulhollandSchool of Civil and Environmental Engineering, Georgia Institute of Technology, 790 Atlantic Drive NW, Atlanta, GA 30332, United States. Electronic address: james.mulholland@ce.gatech.edu.
Andrea WinquistDepartment of Epidemiology, Emory University, 1518 Clifton Rd. NE, Atlanta, GA 30322, United States. Electronic address: awinqui@emory.edu.
Evelyn O TalbottDepartment of Epidemiology, University of Pittsburgh, 130 De Soto Street, Pittsburgh, PA 15261, United States. Electronic address: eot1@pitt.edu.
Judith R RagerDepartment of Epidemiology, University of Pittsburgh, 130 De Soto Street, Pittsburgh, PA 15261, United States. Electronic address: jnrst8@pitt.edu.
Paige E TolbertDepartment of Environmental Health, Emory University, 1518 Clifton Rd. NE, Atlanta, GA 30322, United States. Electronic address: ptolber@emory.edu.
Stefanie Ebelt SarnatDepartment of Environmental Health, Emory University, 1518 Clifton Rd. NE, Atlanta, GA 30322, United States. Electronic address: sebelt@emory.edu.

Funding

Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI Carmen Joseph Marsit · 2013 to 2026
$22.6M
Multiple Pollutants and Cardiorespiratory OutcomesR01ES011294 · NIEHS · EMORY UNIVERSITY · PI TOLBERT, PAIGE E · 2002 to 2005
$1.1M
NIEHS NIH HHS P30 ES019776NIEHS NIH HHS R01 ES011294
6 · The paper itself

Abstract

Determining how associations between ambient air pollution and health vary by specific outcome is important for developing public health interventions. We estimated associations between twelve ambient air pollutants of both primary (e.g. nitrogen oxides) and secondary (e.g. ozone and sulfate) origin and cardiorespiratory emergency department (ED) visits for 8 specific outcomes in five U.S. cities including Atlanta, GA; Birmingham, AL; Dallas, TX; Pittsburgh, PA; St. Louis, MO. For each city, we fitted overdispersed Poisson time-series models to estimate associations between each pollutant and specific outcome. To estimate multicity and posterior city-specific associations, we developed a Bayesian multicity multi-outcome (MCM) model that pools information across cities using data from all specific outcomes. We fitted single pollutant models as well as models with multipollutant components using a two-stage chemical mixtures approach. Posterior city-specific associations from the MCM models were somewhat attenuated, with smaller standard errors, compared to associations from time-series regression models. We found positive associations of both primary and secondary pollutants with respiratory disease ED visits. There was some indication that primary pollutants, particularly nitrogen oxides, were also associated with cardiovascular disease ED visits. Bayesian models can help to synthesize findings across multiple outcomes and cities by providing posterior city-specific associations building on variation and similarities across the multiple sources of available information.

Indexed as

Air PollutantsAir PollutionBayes TheoremCardiovascular DiseasesCitiesEmergency Service, HospitalHumansNitrogen OxidesOzoneParticulate MatterRespiratory Tract DiseasesSulfatesUnited StatesAir PollutantsNitrogen OxidesOzoneParticulate MatterSulfatesAir pollutionBayesian hierarchical modelsCardiorespiratory morbidityHealth associationsTime-series models

Identifiers

PMID30107292
PMCPMC6218942

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.