Evidence map›Paper›PMID 30107198›Full record

ArticleBrain, behavior, and immunity2018

Female mice are protected from space radiation-induced maladaptive responses.

Karen Krukowski, Katherine Grue, Elma S Frias, John Pietrykowski, Tamako Jones, Gregory Nelson, Susanna Rosi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 124 citations in OpenAlex.

  1. Review
  2. Long-term molecular effects ofNPJ microgravity · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Adverse Outcome Pathways Applied to Space Radiation Research.Environmental and molecular mutagenesis · 2025
    Review
  7. Article
  8. Review
  9. Article
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  16. Review
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  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Karen KrukowskiDepartment of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA; Brain and Spinal Injury Center, University of California, San Francisco, CA, USA.
Katherine GrueDepartment of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA; Brain and Spinal Injury Center, University of California, San Francisco, CA, USA.
Elma S FriasDepartment of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA; Brain and Spinal Injury Center, University of California, San Francisco, CA, USA; Biomedical Science Graduate Program, University of California, San Francisco, CA, USA.
John PietrykowskiDepartment of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA; Brain and Spinal Injury Center, University of California, San Francisco, CA, USA.
Tamako JonesDepartment of Basic Sciences, Division of Biomedical Engineering Sciences, Loma Linda University, Loma Linda, CA,USA.
Gregory NelsonDepartment of Basic Sciences, Division of Biomedical Engineering Sciences, Loma Linda University, Loma Linda, CA,USA.
Susanna RosiDepartment of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA; Brain and Spinal Injury Center, University of California, San Francisco, CA, USA; Department of Neurological Surgery, University of California, San Francisco, CA, USA; Weill Institute for Neuroscience, University of California, San Francisco, CA, USA; Kavli Institute of Fundamental Neuroscience, University of California, San Francisco, CA, USA. Electronic address: susanna.rosi@ucsf.edu.
University of California, San Francisco · USLoma Linda University · US

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
Maximizing Opportunities for Research Excellence - Evaluation Training SupplementR25GM056847 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUNCAN, D'ANNE S., SELLO, JASON K · 1998 to 2023
$14.1M
Therapeutic Irradiation and Brain FunctionsR01CA213441 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUPTA, NALIN · 2017 to 2021
$1.8M
Aging exacerbates trauma-induced immune pathways and neuronal dysfunctionR01AG056770 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSI, SUSANNA · 2017 to 2021
$1.7M
Brain Irradiation Affects Neuronal FunctionR01CA133216 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSI, SUSANNA · 2009 to 2013
$1.5M
Effects of traumatic brain injury on hippocampal network activity: age differenceR21AG042016 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSI, SUSANNA · 2013 to 2014
$433k
Impact of aging on immune activation and cognitive decline after traumatic brain injuryF32AG054126 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUKOWSKI, KAREN · 2017 to 2018
$128k
NCI NIH HHS R01 CA133216NCI NIH HHS R01 CA213441NIAID NIH HHS P30 AI027763NIA NIH HHS F32 AG054126NIA NIH HHS R01 AG056770NIA NIH HHS R21 AG042016NIGMS NIH HHS R25 GM056847
6 · The paper itself

Abstract

Interplanetary exploration will be humankind's most ambitious expedition and the journey required to do so, is as intimidating as it is intrepid. One major obstacle for successful deep space travel is the possible negative effects of galactic cosmic radiation (GCR) exposure. Here, we investigate for the first time how combined GCR impacts long-term behavioral and cellular responses in male and female mice. We find that a single exposure to simulated GCR induces long-term cognitive and behavioral deficits only in the male cohorts. GCR exposed male animals have diminished social interaction, increased anxiety-like phenotype and impaired recognition memory. Remarkably, we find that the female cohorts did not display any cognitive or behavioral deficits after GCR exposure. Mechanistically, the maladaptive behavioral responses observed only in the male cohorts correspond with microglia activation and synaptic loss in the hippocampus, a brain region involved in the cognitive domains reported here. Furthermore, we measured reductions in AMPA expressing synaptic terminals in the hippocampus. No changes in any of the molecular markers measured here are observed in the females. Taken together these findings suggest that GCR exposure can regulate microglia activity and alter synaptic architecture, which in turn leads to a range of cognitive alterations in a sex dependent manner. These results identify sex-dependent differences in behavioral and cognitive domains revealing promising cellular and molecular intervention targets to reduce GCR-induced chronic cognitive deficits thereby boosting chances of success for humans in deep space missions such as the upcoming Mars voyage.

Indexed as

Sex FactorsAnimalsBehavior, AnimalCognitive DysfunctionCosmic RadiationFemaleMaleMiceMice, Inbred C57BLMicrogliaModels, AnimalSpace FlightSynapsesGalactic cosmic rayMicrogliaRadiationSex-differencesSynapse

Identifiers

PMID30107198
PMCPMC8715721
OpenAlexW2886681222

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.